Evidence map›Paper›PMID 31602275›Full record

ArticleJournal of Cancer2019

8-bromo-7-methoxychrysin targets NF-κB and FoxM1 to inhibit lung cancer stem cells induced by pro-inflammatory factors.

Qing Yuan, Min Wen, Chang Xu, A Chen, Ye-Bei Qiu, Jian-Guo Cao, Jian-Song Zhang, Zhen-Wei Song

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Qing YuanDepartment of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
Min WenDepartment of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
Chang XuDepartment of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
A ChenDepartment of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
Ye-Bei QiuDepartment of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
Jian-Guo CaoDepartment of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha, 410013, China.
Jian-Song ZhangDepartment of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
Zhen-Wei SongDepartment of preclinical medicine, Medical College, Hunan Normal University, Changsha, 410013, China.
Hunan Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously reported that 8-bromo-7-methoxychrysin (BrMC), a novel synthetic derivative of chrysin, was demonstrated anti-tumor activities against several human cancers, including lung cancer. Interaction between inflammation and cancer stem cell are recently increasingly recognized in tumorigenesis and progression. The purpose of this study was to investigate whether BrMC inhibits lung cancer stemness of H460 cells induced by inflammatory factors (TGF-β combined with TNF-α) and its potential mechanism. Our results showed that BrMC inhibited lung cancer stemness, as validated by enhanced self-renewal ability, higher

Indexed as

cancer stem cellFoxM1inflammatory factorlung cancerNF-κBtumorigenesis

Identifiers

PMID31602275
PMCPMC6775618
OpenAlexW2978452687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.