Evidence map›Paper›PMID 31602200›Full record

ArticleExperimental and therapeutic medicine2019

High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support.

Natalie E Stevens, Coralie H Nash, Cara K Fraser, Tim R Kuchel, Matthew J Maiden, Marianne J Chapman, Kerrilyn R Diener, John D Hayball

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Natalie E StevensExperimental Therapeutics Laboratory, University of South Australia Cancer Research Institute, Adelaide, SA 5000, Australia.
Coralie H NashDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
Cara K FraserPreclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Gilles Plain, SA 5086, Australia.
Tim R KuchelPreclinical, Imaging and Research Laboratories, South Australian Health and Medical Research Institute, Gilles Plain, SA 5086, Australia.
Matthew J MaidenDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
Marianne J ChapmanDiscipline of Acute Care Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
Kerrilyn R DienerExperimental Therapeutics Laboratory, University of South Australia Cancer Research Institute, Adelaide, SA 5000, Australia.
John D HayballExperimental Therapeutics Laboratory, University of South Australia Cancer Research Institute, Adelaide, SA 5000, Australia.
University of Adelaide · AUCentre for Cancer Biology · AUSouth Australian Health and Medical Research Institute · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a highly complex and often fatal syndrome which varies widely in its clinical manifestations, and therapies that target the underlying uncontrolled immune status in sepsis are needed. The failure of preclinical approaches to provide significant sepsis survival benefit in the clinic is often attributed to inappropriate animal disease models. It has been demonstrated that high mobility group box protein 1 (HMGB1) blockade can reduce inflammation, mortality and morbidity in experimental sepsis without promoting immunosuppression. Within this study, we explored the use of ovine anti-HMGB1 antibodies in a model of ovine septic shock incorporating intensive care supports (OSSICS). Results: Septic sheep exhibited elevated levels of HMGB1 within 12 h after the induction of sepsis. In this study, sepsis was induced in six anaesthetized adult Border Leicester × Merino ewes via intravenous instillation of

Indexed as

animal modelsHMGB1pAb(s)sepsissheep

Identifiers

PMID31602200
PMCPMC6777221
OpenAlexW2970153456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.