Evidence map›Paper›PMID 31601924›Full record

ArticleScientific reports2019

Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells.

Margaux A C Fontaine, Marijke M Westra, Ilze Bot, Han Jin, Aimée J P M Franssen, Martine Bot, Saskia C A de Jager, Ivan Dzhagalov, You-Wen He, Bart J M van Vlijmen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Margaux A C FontaineExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0003-2882-1313
Marijke M WestraDivision of BioTherapeutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Ilze BotDivision of BioTherapeutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-1242-1959
Han JinExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Aimée J P M FranssenExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Martine BotDivision of BioTherapeutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Saskia C A de JagerDivision of BioTherapeutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Ivan DzhagalovInstitue of Microbiology and Immunology, National Yang-Ming University, Taipei, 112, Taiwan.
You-Wen HeInstitue of Microbiology and Immunology, National Yang-Ming University, Taipei, 112, Taiwan.
Bart J M van VlijmenEinthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Marion J J GijbelsExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Chris P ReutelingspergerDepartment of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-2334-9403
Theo J C van BerkelDivision of BioTherapeutics, Leiden Amsterdam Centre for Drug Research, Leiden University, Leiden, the Netherlands.
Judith C SluimerExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-0269-4582
Lieve TemmermanExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands. lieve.temmerman@mumc.nl.
Erik A L BiessenExperimental Vascular Pathology Group, Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, the Netherlands.
Maastricht University · NLLeiden University · NLNational Yang Ming Chiao Tung University · TWLeiden University Medical Center · NLMaastricht University Medical Centre · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) plays an important role in survival and differentiation of leukocytes, more specifically of neutrophils. Here, we investigated the impact of myeloid Mcl-1 deletion in atherosclerosis. Western type diet fed LDL receptor-deficient mice were transplanted with either wild-type (WT) or LysMCre Mcl-1

Indexed as

Apoptosis3T3 CellsAnimalsAtherosclerosisCell DifferentiationGene DeletionGiant CellsHumansImmunohistochemistryLipidsMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicMyeloid Cell Leukemia Sequence 1 ProteinLipidsMCL1 protein, humanMcl1 protein, mouseMyeloid Cell Leukemia Sequence 1 Protein

Identifiers

PMID31601924
PMCPMC6787218
OpenAlexW2979714073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.