ArticleScientific reports2019
In vitro Antimicrobial Activity of Acne Drugs Against Skin-Associated Bacteria.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate.Journal of cosmetic dermatology · 2025Trial
- Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug.American journal of clinical dermatology · 2022Trial
- Advanced azelaic acid hyalubilosome-loaded microneedles for potent anti-inflammatory, antioxidant, and antimicrobial for Acne treatment by up-regulation of Nrf2/HO-1 signaling pathway.International journal of pharmaceutics: X · 2026Article
- Article
- Improvement of Overall Skin Condition in Acne and Oily Prone Skin With an Amino Acid Cleanser Containing Salicylic Acid, Glucuronolactone, and Ceramides.Journal of cosmetic dermatology · 2026Article
- Selected medium-chain dicarboxylic acids: alternative preservatives in improving shelf-life and quality of meat products.Food science and biotechnology · 2025Review
- Optimization of Anthralin Microemulgel Targeted Delivery for Psoriasis and Acne.Molecules (Basel, Switzerland) · 2025Article
- Topical administration of mupirocin ointment and fusidic acid in bacterial infection-induced skin diseases.Postepy dermatologii i alergologii · 2025Article
- Criticality of Benzoyl Peroxide and Antibiotic Fixed Combinations in Combating Rising Resistance inClinical, cosmetic and investigational dermatology · 2025Article
- Antibacterial, Antifungal, Antiviral Activity, and Mechanisms of Action of Plant Polyphenols.Microorganisms · 2024Review
- Antimicrobial Activities of Natural Bioactive Polyphenols.Pharmaceutics · 2024Review
- Medium-chain dicarboxylic acids: chemistry, pharmacological properties, and applications in modern pharmaceutical and cosmetics industries.RSC advances · 2024Review
- Review
- Characterization and Engineering Studies of a New Endolysin from theInternational journal of molecular sciences · 2023Article
- A novel long-acting antimicrobial nanomicelle spray.Nanoscale advances · 2023Article
- Extraction and Quantification of Azelaic Acid from Different Wheat Samples (Molecules (Basel, Switzerland) · 2023Article
- Medical Applications of Hydrogels in Skin Infections: A Review.Infection and drug resistance · 2023Review
- Indonesian MangroveMolecules (Basel, Switzerland) · 2022Article
- In Vitro Antimicrobial Activity ofAnimals : an open access journal from MDPI · 2022Article
- Hydrogel composite containing azelaic acid and tea tree essential oil as a therapeutic strategy for Propionibacterium and testosterone-induced acne.Drug delivery and translational research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Acne is a common skin affliction that involves excess sebum production and modified lipid composition, duct blockage, colonization by bacteria, and inflammation. Acne drugs target one or more of these steps, with antibiotics commonly used to treat the microbial infection for moderate to severe cases. Whilst a number of other acne therapies are purported to possess antimicrobial activity, this has been poorly documented in many cases. We conducted a comparative analysis of the activity of common topical acne drugs against the principal etiological agent associated with acne: the aerotolerant anaerobic Gram-positive organism Propionibacterium acnes (recently renamed as Cutibacterium acnes). We also assessed their impact on other bacteria that could also be affected by topical treatments, including both antibiotic-sensitive and antibiotic-resistant strains, using broth microdilution assay conditions. Drugs designated specifically as antibiotics had the greatest potency, but lost activity against resistant strains. The non-antibiotic acne agents did possess widespread antimicrobial activity, including against resistant strains, but at substantially higher concentrations. Hence, the antimicrobial activity of non-antibiotic acne agents may provide protection against a background of increased drug-resistant bacteria.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.