Evidence map›Paper›PMID 31601831›Full record

ArticleScientific reports2019

Quantifying muscle glycosaminoglycan levels in patients with post-stroke muscle stiffness using T

Rajiv G Menon, Preeti Raghavan, Ravinder R Regatte

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06060925 completednot on this mapstarted 2023, after this paper: background citation

Multimodal Imaging Biomarkers for Investigating Fascia, Muscle and Vasculature in Myofascial Pain

TypeobservationalSponsorGeorge Mason UniversityRan2023 to 2025Enrolled96ConditionsMyofascial Pain Syndrome, HealthyArmsUltrasound imaging, Bioimpedance spectroscopy, Electromyography, Physical examination
NCT06910254 nacompletednot on this mapstarted 2025, after this paper: background citation

Effects of Overground Robot-Assisted Gait Training and Recumbent Bicycle Training on Muscle Characteristics, Falls Efficacy, and Physical Function in Patients With Subacute Stroke-Related Sarcopenia

TypeinterventionalSponsorSahmyook UniversityRan2025 to 2025Enrolled53ConditionsStroke, Sarcopenia, Muscle Atrophy, Mobility LimitationArmsOverground Robot-Assisted Gait Training (o-RAGT), Recumbent Bicycle Training
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Review
  4. Hyaluronan in cardiac disease: implications for the extracellular matrix beyond collagen.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  5. Article
  6. Article
  7. Multiparametric quantitative magnetic resonance imaging of skeletal muscle in CKD.American journal of physiology. Renal physiology · 2025
    Article
  8. ISSLS Prize in Basic Science 2025: Structural changes of muscle spindles in the multifidus muscle after intervertebral disk injury are resolved by targeted activation of the muscle.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Hyaluronan homeostasis and its role in pain and muscle stiffness.PM & R : the journal of injury, function, and rehabilitation · 2022
    Review
  16. Densification: Hyaluronan Aggregation in Different Human Organs.Bioengineering (Basel, Switzerland) · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Rajiv G MenonBernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, USA. rajiv.menon@nyulangone.org.ORCID http://orcid.org/0000-0001-6160-886X
Preeti RaghavanDepts. of Physical Medicine and Rehabilitation and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ravinder R RegatteBernard and Irene Schwartz Center for Biomedical Imaging, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-4607-7682
Johns Hopkins University · USNew York Proton Center · USNew York University · US

Funding

TR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hersh Chandarana · 2014 to 2026
$19.3M
Imaging Biomarkers of Knee OsteoarthritisR01AR068966 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2016 to 2021
$3.1M
Assessment of Cartilage Repair with Sodium MRI at 3TR01AR067156 · NIAMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REGATTE, RAVINDER · 2015 to 2019
$2.3M
Peripheral Modulation of Muscle Stiffness and SpasticityR21HD091559 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAGHAVAN, PREETI · 2017 to 2017
$253k
NIAMS NIH HHS R01 AR067156NIAMS NIH HHS R01 AR068966NIBIB NIH HHS P41 EB017183NICHD NIH HHS R21 HD091559
6 · The paper itself

Abstract

The purpose of this study was to provide imaging evidence of increased glycosaminoglycan (GAG) content in patients with post-stroke muscle stiffness; and to determine the effect of hyaluronidase treatment on intramuscular GAG content. In this prospective study, we used 3D-T

Indexed as

Magnetic Resonance ImagingAdultCartilage, ArticularFemaleGlycosaminoglycansHumansHyaluronoglucosaminidaseMaleMiddle AgedMuscle, SkeletalMuscle StrengthGlycosaminoglycansHyaluronoglucosaminidase

Identifiers

PMID31601831
PMCPMC6787087
OpenAlexW2979483197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.