ArticleNature communications2019
Consciousness-specific dynamic interactions of brain integration and functional diversity.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers, 2 of them syntheses that pooled it.
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Who cites it
134 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A methodological guideline for consciousness assessment via neural electrophysiological activity.Military Medical Research · 2025Guideline
- Prediction models for functional outcomes in prolonged disorders of consciousness: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Effect and mechanism of repetitive transcranial magnetic stimulation of angular gyrus on patients with consciousness disorder.Frontiers in neurologyTrial
- Architectural reorganization of functional connectivity after propofol anesthesia exceeds within-state measurement variability and is only marginally reversed during early recovery.Neuroimage. Reports · 2026Article
- Intrinsic functional architecture predicts remote motor cortical excitability changes induced by intermittent theta-burst stimulation.iScience · 2026Article
- Detecting EEG index of arousal in sleeping patients with unresponsive wakefulness syndrome.iScience · 2026Article
- Comprehensive profiling of brain dynamics during anesthesia across phylogeny.Nature neuroscience · 2026Article
- Differential Dynamic Reorganization of Functional Connectivity Based on Phase Synchrony and Amplitude Envelope Coupling During Propofol Sedation.Brain sciences · 2026Article
- Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment.Experimental & molecular medicine · 2026Article
- HESREN: A Derivative-Informed Reservoir Framework for Detecting Transient Neural Events and Windowless Estimation of Dynamic Functional Connectivity.Neuroinformatics · 2026Article
- Reorganization of Human Brain Waves Across Diverse States of Consciousness.bioRxiv : the preprint server for biology · 2026Article
- An Orthogonal Semi-Nonnegative Matrix Factorization Method for Dynamic Functional Connectivity Analysis and Its Application to Schizophrenia.IEEE journal of biomedical and health informatics · 2026Article
- The role of transthalamic pathways in perception.Communications biology · 2026Review
- When does consciousness arise? A subcortical model of its origins.Brain structure & function · 2026Review
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Neurophysiological connectomic signatures of consciousness during propofol-induced general anesthesia.Cell reports. Medicine · 2026Article
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The neural correlates of shared and individual experience.Communications biology · 2026Article
- A thalamic perspective of (un)consciousness in pharmacological and pathological states in humans.Brain communications · 2026Article
74 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
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Abstract
Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to identify consciousness-specific patterns of brain function. We demonstrate that cortical networks are especially affected by loss of consciousness during temporal states of high integration, exhibiting reduced functional diversity and compromised informational capacity, whereas thalamo-cortical functional disconnections emerge during states of higher segregation. Spatially, posterior regions of the brain's default mode network exhibit reductions in both functional diversity and integration with the rest of the brain during unconsciousness. These results show that human consciousness relies on spatio-temporal interactions between brain integration and functional diversity, whose breakdown may represent a generalisable biomarker of loss of consciousness, with potential relevance for clinical practice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.