Evidence map›Paper›PMID 31601786›Full record

ArticleExperimental & molecular medicine2019

Methylation determines the extracellular calcium sensitivity of the leak channel NALCN in hippocampal dentate granule cells.

Seul-Yi Lee, Tuan Anh Vuong, Xianlan Wen, Hyeon-Ju Jeong, Hyun-Kyung So, Ilmin Kwon, Jong-Sun Kang, Hana Cho

Open access · goldAbstract read
In one paragraph

Article in Experimental & molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Seul-Yi Lee *Department of Physiology, Sungkyunkwan University, Suwon, Korea.ORCID http://orcid.org/0000-0002-9360-131X
Tuan Anh Vuong *Single Cell Network Research Center, Sungkyunkwan University, Suwon, Korea.
Xianlan Wen *Department of Physiology, Sungkyunkwan University, Suwon, Korea.
Hyeon-Ju JeongSingle Cell Network Research Center, Sungkyunkwan University, Suwon, Korea.
Hyun-Kyung SoSingle Cell Network Research Center, Sungkyunkwan University, Suwon, Korea.
Ilmin KwonDepartment of Anatomy and Cell Biology, Sungkyunkwan University, Suwon, Korea.
Jong-Sun KangSingle Cell Network Research Center, Sungkyunkwan University, Suwon, Korea. Kangj01@skku.edu.
Hana ChoDepartment of Physiology, Sungkyunkwan University, Suwon, Korea. hanacho@skku.edu.
Sungkyunkwan University · KR

Funding

National Research Foundation of Korea (NRF) 2017R1A2B2010237National Research Foundation of Korea (NRF) 2019R1A2C2006233
6 · The paper itself

Abstract

The sodium leak channel NALCN is a key player in establishing the resting membrane potential (RMP) in neurons and transduces changes in extracellular Ca

Indexed as

AnimalsArginineBrain DiseasesCalcium SignalingHEK293 CellsHippocampusHumansIntellectual DisabilityIon ChannelsMembrane PotentialsMembrane ProteinsMethylationMiceNeuronsPhosphorylationProtein-Arginine N-MethyltransferasesArginineIon ChannelsMembrane ProteinsNALCN protein, humanPRMT7 protein, humanPRMT7 protein, mouseProtein-Arginine N-MethyltransferasesReceptors, Calcium-Sensing

Identifiers

PMID31601786
PMCPMC6802672
OpenAlexW2979720830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.