ArticleScience (New York, N.Y.)2019
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep.
Article in Science (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.
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140 citing papers in PubMed, 266 citations in OpenAlex.
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- Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Circadian biology and exercise: the time to move.Life metabolism · 2026Review
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- Sleep regulates drug seeking and relapse - a perspective.Molecular psychiatry · 2026Review
- Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Brain Transcriptomics Across Diverse Sleep-Wake Manipulations Reveals Multiple Homeostatic Pathways inbioRxiv : the preprint server for biology · 2026Article
- The mPFC molecular clock mediates the effects of sleep deprivation on depression-like behavior and regulates sleep consolidation and homeostasis.Molecular psychiatry · 2026Article
- Diurnal Regulation and Gene-Specific Vulnerability of Oxidative Alcohol-Metabolizing Enzymes to Circadian Disruption.International journal of molecular sciences · 2026Article
- Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging.Npj biological timing and sleep · 2026Article
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Dim light at night disrupts the sleep-wake cycle and exacerbates abnormal EEG activity in Cntnap2 knockout mice: implications for autism spectrum disorders.Molecular autism · 2025Article
- Dim light at night disrupts the sleep-wake cycle and exacerbates abnormal EEG activity in Cntnap2 knockout mice: implications for autism spectrum disorders.Molecular autism · 2025Article
- Latent mechanisms of plasticity are upregulated during sleep.Current opinion in neurobiology · 2025Review
- Role of d-serine in intestinal ROS accumulation after sleep deprivation.Science advances · 2025Article
- Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex.NeuroSci · 2025Article
- Transcriptional dynamics of sleep deprivation and subsequent recovery sleep in the male mouse cortex.Physiological genomics · 2025Article
80 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons have adapted mechanisms to traffic RNA and protein into distant dendritic and axonal arbors. Taking a biochemical approach, we reveal that forebrain synaptic transcript accumulation shows overwhelmingly daily rhythms, with two-thirds of synaptic transcripts showing time-of-day-dependent abundance independent of oscillations in the soma. These transcripts formed two sharp temporal and functional clusters, with transcripts preceding dawn related to metabolism and translation and those anticipating dusk related to synaptic transmission. Characterization of the synaptic proteome around the clock demonstrates the functional relevance of temporal gating for synaptic processes and energy homeostasis. Unexpectedly, sleep deprivation completely abolished proteome but not transcript oscillations. Altogether, the emerging picture is one of a circadian anticipation of messenger RNA needs in the synapse followed by translation as demanded by sleep-wake cycles.
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