ArticleProceedings of the National Academy of Sciences of the United States of America2019
Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
70 citing papers in PubMed.
- IoT-enabled wireless neural implant for chronic, programmable neuropharmacology and optogenetics.Science advances · 2026Article
- Nanofluidic-based electrochemical pump for remotely controlled, on-demand drug delivery.Lab on a chip · 2026Article
- Review
- Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission.Frontiers in molecular neuroscience · 2026Review
- Fully Implanted Miniature Radio Controller Boosts Cyborg Insect Mobility in Challenging Terrains.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- An Implantable, Ultralow Distortion Bioelectronic Interface Integrating Light-Emitting Diodes and Graphene Field-Effect Transistors.ACS nano · 2025Article
- Design considerations for optogenetic applications of soft micro-LED-based device systems across diverse nervous systems.Bioactive materials · 2025Review
- An integrated microfluidic and fluorescence platform for probing in vivo neuropharmacology.Neuron · 2025Article
- Wireless Devices for Optical Brain Stimulation: A Review of Current Developments for Optogenetic Applications in Freely Moving Mice.Cellular and molecular bioengineering · 2025Review
- Liquid-based encapsulation for implantable bioelectronics across broad pH environments.Nature communications · 2025Article
- Genetic engineering frontiers in cell manipulation-based tissue engineering: A comprehensive review.BioImpacts : BI · 2025Review
- Wireless, Programmable, and Refillable Hydrogel Bioelectronics for Enhanced Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Stretchable and biodegradable self-healing conductors for multifunctional electronics.Science advances · 2024Article
- Optogenetics in oral and craniofacial research.Journal of Zhejiang University. Science. B · 2024Review
- A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation.Nature communications · 2024Article
- Elucidating and Optimizing the Photochemical Mechanism of Coumarin-Caged Tertiary Amines.Journal of the American Chemical Society · 2024Article
- Review
- Design and validation of a low-cost photomodulator for in vivo photoactivation of a mGluR5 inhibitor.Biomedical engineering letters · 2024Article
- A Miniaturized Wireless Micropump Enabled by Confined Acoustic Streaming.Research (Washington, D.C.) · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Funding
Abstract
Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.