Evidence map›Paper›PMID 31601716›Full record

ArticleThe European respiratory journal2020

Bilateral hypoglossal nerve stimulation for treatment of adult obstructive sleep apnoea.

Peter R Eastwood, Maree Barnes, Stuart G MacKay, John R Wheatley, David R Hillman, Xuân-Lan Nguyên, Richard Lewis, Matthew C Campbell, Boris Pételle, Jennifer H Walsh and 12 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03048604 (A Multicentre, Prospective, Open-label, Non-randomized, Single Arm Treatment Study to Assess the Safety, Performance and Initial Efficacy Trends of the Genio), which is not on this map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03048604 nacompletednot on this map

A Multicentre, Prospective, Open-label, Non-randomized, Single Arm Treatment Study to Assess the Safety, Performance and Initial Efficacy Trends of the Genio(TM) Bilateral Hypoglossal Nerve Stimulation System for the Treatment of Obstructive Sleep Apnoea.

TypeinterventionalSponsorNyxoah S.A.Ran2017 to 2018Enrolled27ConditionsObstructive Sleep Apnea of AdultArmsGenio(TM) bilateral hypoglossal nerve stimulation system
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Referral of adults with obstructive sleep apnea for surgical consultation: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Pooled it
  2. Pooled it
  3. Bilateral hypoglossal nerve stimulation for obstructive sleep apnea: a nonrandomized clinical trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Trial
  4. Effect of hypoglossal nerve stimulation on snoring: an evaluation using objective acoustic parameters.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  5. Review
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  7. Review
  8. Article
  9. Review
  10. Article
  11. Redefining Obstructive Sleep Apnea: Treatment in the Modern Era.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. COJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 9 institutions in 3 countries.

Peter R EastwoodCentre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, Australia peter.eastwood@health.wa.gov.au.ORCID 0000-0002-4490-4138
Maree BarnesInstitute for Breathing and Sleep, Austin Hospital, Heidelberg, Australia.
Stuart G MacKayIllawarra ENT Head and Neck Clinic, Wollongong, Australia.
John R WheatleyDept of Respiratory and Sleep Medicine, Westmead Hospital, Westmead, Australia.
David R HillmanCentre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, Australia.
Xuân-Lan NguyênUnité de Somnologie et Fonction Respiratoire, Hopital St Antoine, Paris, France.
Richard LewisDept Otolaryngology, Head and Neck Surgery, Royal Perth Hospital, Perth, Australia.
Matthew C CampbellInstitute for Breathing and Sleep, Austin Hospital, Heidelberg, Australia.
Boris PételleService ORL Chirurgie de la Face et du Cou, Hôpital Tenon, AP-HP, Paris, Sorbonne Université, Paris, France.
Jennifer H WalshCentre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, Australia.
Andrew C JonesIllawarra ENT Head and Neck Clinic, Wollongong, Australia.
Carsten E PalmeUniversity of Sydney at Westmead Hospital, Westmead, Australia.
Alain BizonDept Otolaryngology, Head and Neck Surgery, University Hospital of Angers, Angers, France.
Nicole MeslierDept of Respiratory and Sleep Medicine, University Hospital of Angers, Angers, France.
Chloé BertolusAP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service des Pathologies du Sommeil (Département "R3S"), Paris, France.
Kathleen J MaddisonCentre for Sleep Science, School of Human Sciences, University of Western Australia, Perth, Australia.
Laurent LaccourreyeDept Otolaryngology, Head and Neck Surgery, University Hospital of Angers, Angers, France.
Guillaume RauxNyxoah, S.A., Mont-Saint-Guibert, Belgium.
Katleen DenoncinNyxoah, S.A., Mont-Saint-Guibert, Belgium.
Valérie AttaliSorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Frédéric GagnadouxDept of Respiratory and Sleep Medicine, University Hospital of Angers, Angers, France.
Sandrine H LaunoisUnité de Somnologie et Fonction Respiratoire, Hopital St Antoine, Paris, France.
Inserm · FRThe University of Western Australia · AUNyxoah (Belgium) · BESorbonne Université · FRThe University of Melbourne · AUThe University of Sydney · AUUniversité d'Angers · FRUniversity of Wollongong · AURoyal Perth Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimHypoglossal nerve stimulation (HNS) decreases obstructive sleep apnoea (OSA) severity

methodsThis prospective, open-label, non-randomised, single-arm treatment study was conducted at eight centres in three countries (Australia, France and the UK). Primary outcomes were incidence of device-related serious adverse events and change in the apnoea-hypopnoea index (AHI). The secondary outcome was the change in the 4% oxygen desaturation index (ODI). Additional outcomes included measures of sleepiness, quality of life, snoring and device use. This trial was registered with ClinicalTrials.gov, number NCT03048604.

results22 out of 27 implanted participants (63% male, aged 55.9±12.0 years, body mass index (BMI) 27.4±3.0 kg·m

conclusionsBilateral HNS using the Genio™ system reduces OSA severity and improves quality of life without device-related complications. The results are comparable with previously published HNS systems despite minimal implanted components and a simple stimulation algorithm.

Indexed as

Hypoglossal NerveSleep Apnea, ObstructiveAdultAustraliaFemaleFranceHumansMaleProspective StudiesQuality of LifeTreatment Outcome

Identifiers

PMID31601716
PMCPMC6949509
OpenAlexW2979630529

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.