Evidence map›Paper›PMID 31601687›Full record

ArticleHaematologica2020

Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis.

Shufen Wang, Xuyan He, Qian Wu, Li Jiang, Liyun Chen, Yingying Yu, Pan Zhang, Xin Huang, Jia Wang, Zhenyu Ju and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Ferroptosis: A Novel Mechanism in Diabetic Keratopathy.Investigative ophthalmology & visual science · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Shufen WangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Xuyan HeThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Qian WuThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Li JiangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Liyun ChenThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Yingying YuThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Pan ZhangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou.
Xin HuangDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou.
Jia WangDepartment of Nutrition, Precision Nutrition Innovation Center, School of Public Health, Zhengzhou University, Zhengzhou.
Zhenyu JuKey Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, China.
Junxia MinThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou junxiamin@zju.edu.cn.
Fudi WangThe First Affiliated Hospital, School of Public Health, Institute of Translational Medicine, Zhenjiang Provincial Key Laboratory of Pancreatic Disease, Zhejiang University School of Medicine, Hangzhou fwang@zju.edu.cn.
Zhejiang University · CNChina Agricultural University · CNZhengzhou University · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transferrin receptor 1 (Tfr1) mediates the endocytosis of diferric transferrin in order to transport iron, and Tfr1 has been suggested to play an important role in hematopoiesis. To study the role of Tfr1 in hematopoiesis, we generated hematopoietic stem cell (HSC) specific Tfr1 knockout mice. We found that

Indexed as

IronReceptors, TransferrinAnimalsBiological TransportHematopoiesisMiceMice, KnockoutTransferrinIronReceptors, TransferrinTransferrin

Identifiers

PMID31601687
PMCPMC7395265
OpenAlexW2979812524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.