ArticleThe Journal of cell biology2019
Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.
Open access · hybridAbstract read
In one paragraph
Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- STIM-Orai signaling in neurons: integrating calcium dynamics and synaptic plasticity.Cell communication and signaling : CCS · 2026Review
- Nanoscale CabioRxiv : the preprint server for biology · 2026Article
- Changes in the endoplasmic reticulum‑mitochondria communication in dermal fibroblasts from early‑stage bipolar disorder patients: Skin‑brain axis as a new route to understand the pathophysiology of mental illness?International journal of molecular medicine · 2025Article
- Inhibition of NPC Intracellular Cholesterol Transporter 1 Dually Regulates Aldosterone Secretion Via the Steroidogenic Acute Regulatory-Related Lipid Transfer Domain-3-Voltage-Dependent Anion Channel 1 Axis and Inositol 1,4,5-Trisphosphate Receptor Type 3-Calcium Signaling.Journal of the American Heart Association · 2025Article
- Unlocking the lipid code: SREBPs as key drivers in gastrointestinal tumour metabolism.Lipids in health and disease · 2025Review
- Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C.International journal of molecular sciences · 2025Article
- Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis.Frontiers in pharmacology · 2025Article
- Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann-Pick Disease Type C.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies.JCI insight · 2024Article
- Unraveling the Connection: Cholesterol, Calcium Signaling, and Neurodegeneration.Neuroscience insights · 2024Article
- Niemann-Pick Disease Type C (NPDC) by Mutation ofAntioxidants (Basel, Switzerland) · 2023Review
- α-Synuclein-dependent increases in PIP5K1γ drive inositol signaling to promote neurotoxicity.Cell reports · 2023Article
- Peripheral immune system modulates Purkinje cell degeneration in Niemann-Pick disease type C1.Life science alliance · 2023Article
- Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023Review
- NPC1-dependent alterations in KNature communications · 2023Article
- Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation.iScience · 2023Article
- Disruptive lysosomal-metabolic signaling and neurodevelopmental deficits that precede Purkinje cell loss in a mouse model of Niemann-Pick Type-C disease.Scientific reports · 2023Article
- StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival.Journal of cell science · 2023Article
- c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases.Neural regeneration research · 2023Review
- SKF96365 impedes spinal glutamatergic transmission-mediated neuropathic allodynia.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023Article
Corrections and comments
- Commented on by
Authors and funding
8 authors at 2 institutions in 1 country.
Scott A TiscioneDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA.
Oscar VivasDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA.ORCID 0000-0002-0964-385X
Kenneth S GinsburgDepartment of Pharmacology, University of California, Davis, Davis, CA.
Donald M BersDepartment of Pharmacology, University of California, Davis, Davis, CA.ORCID 0000-0002-2237-9483
Daniel S OryDepartment of Internal Medicine, Washington University School of Medicine, St. Louis, MO.
Luis F SantanaDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA.ORCID 0000-0002-4297-8029
Rose E DixonDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA.ORCID 0000-0003-0655-690X
Eamonn J DicksonDepartment of Physiology and Membrane Biology, University of California, Davis, Davis, CA ejdickson@ucdavis.edu.ORCID 0000-0001-8619-7630
University of California, Davis · USWashington University in St. Louis · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MSPECIALIZED PROGRAMS IN CELLULAR/ MOLECULAR NEUROBIOLOGYU54NS039405 · NINDS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FRONTERA, WALTER R. · 1999 to 2011
$12.9MPost-lysosomal cholesterol trafficking networksR01HL067773 · NHLBI · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 2002 to 2021
$6.3MNFAT-induced Regional Variations in Kv4 Channel Expression in HeartR01HL085686 · NHLBI · UNIVERSITY OF WASHINGTON · PI SANTANA, LUIS F · 2007 to 2020
$5.7MCaMKII activation and regulation in adult cardiac myocytesR01HL142282 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M, BOSSUYT, JULIE B · 2018 to 2025
$5.4MMolecular choreography of CaV1.2 channels in the aging myocardiumR01AG063796 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Rose Ellen Dixon · 2019 to 2026
$3.1MPredoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2MMembrane contact sites regulate cellular excitabilityR01GM127513 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DICKSON, EAMONN JAMES · 2019 to 2023
$1.6MNHLBI NIH HHS R01 HL067773NHLBI NIH HHS R01 HL085686NHLBI NIH HHS R01 HL142282NIA NIH HHS R01 AG063796NIDDK NIH HHS P30 DK056341NIGMS NIH HHS R01 GM127513NIGMS NIH HHS T32 GM099608NINDS NIH HHS U54 NS039405
Abstract
Niemann-Pick type C1 (NPC1) protein is essential for the transport of externally derived cholesterol from lysosomes to other organelles. Deficiency of NPC1 underlies the progressive NPC1 neurodegenerative disorder. Currently, there are no curative therapies for this fatal disease. Given the Ca
Indexed as
Calcium SignalingNeuronal PlasticityAnimalsCarrier ProteinsCholesterolDendritic SpinesEndoplasmic ReticulumFibroblastsHippocampusHumansIntracellular Signaling Peptides and ProteinsLysosomesMaleMiceMice, Inbred C57BLMutationCarrier ProteinsCholesterolIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsNiemann-Pick C1 ProteinNPC1 protein, humanORAI1 ProteinORAI1 protein, humanPresenilin-1PSEN1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.