Evidence map›Paper›PMID 31601581›Full record

ArticleBMJ open2019

Healthy Ageing and Biomarkers Cohort Study (HABCS): a cohort profile.

Yuebin Lv, Chen Mao, Zhaoxue Yin, Furong Li, Xianbo Wu, Xiaoming Shi

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The SG90 cohort of the oldest-old in Singapore.European journal of epidemiology · 2025
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  6. Observational
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  8. Review
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  12. Article
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  15. Vitamin BBMC geriatrics · 2024
    Article
  16. Article
  17. Article
  18. Synaptic resilience is associated with maintained cognition during ageing.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yuebin Lv *National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Chen Mao *Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Zhaoxue YinDivision of Non-Communicable Disease Control and Community Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Furong LiDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Xianbo WuDepartment of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
Xiaoming ShiNational Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China shixm@chinacdc.cn.
Chinese Center For Disease Control and Prevention · CNSouthern Medical University · CN

Funding

Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Virginia B Kraus · 2006 to 2026
$24.6M
THE RANGE OF MALE-FEMALE MORTALITY DIFFERENCESP01AG031719 · NIA · DUKE UNIVERSITY · PI ZENG, YI · 2009 to 2020
$10.2M
NIA NIH HHS P01 AG031719NIA NIH HHS P30 AG028716
6 · The paper itself

Abstract

purposeThe Chinese Longitudinal Healthy Longevity Survey Biomarkers Cohort (Healthy Ageing and Biomarkers Cohort Study (HABCS)) was established to investigate the determinants of healthy aging and mortality among the oldest old in China. Besides collecting health status, behavioural and sociodemographic circumstances, the present study also gathers comprehensive data for the elderly by simultaneously collecting, detecting, analysing blood and urine, respectively.

participantsHABCS is a community-based longitudinal multiwave study of older men and women aged 65 or above. Baseline survey and the follow-up surveys with replacement for deceased elderly were conducted in eight longevity areas in China, which cover the northern, middle and southern parts of China. Between 2008 and 2017, 6333 participants were included in HABCS, comprising 1385 centenarians, 1350 nonagenarians, 1294 octogenarians, 1577 younger elderly (aged 65-79). FINDINGS TO DATE: We have found that higher baseline levels of (1) total cholesterol, (2) low-density lipoprotein cholesterol (LDL-C) and (3) superoxide dismutase activity were associated with greater cognitive decline. While (4) higher LDL-C level was associated with lower risk of all-cause mortality. There was a reverse association between (5) plasma vitamin D and cognitive impairment in cross-sectional and prospective study. FUTURE PLANS: We are currently exploring the relationships between various biomarkers and different outcomes such as cognitive function and mortality. This longitudinal cohort study will be continued in the future.

Indexed as

Healthy AgingAgedAged, 80 and overBiomarkersChinaCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleProspective StudiesBiomarkersChinese oldest oldCohort ProfileHABCSThe Healthy Aging and Biomarkers Cohort Study

Identifiers

PMID31601581
PMCPMC6797363
OpenAlexW2979443992

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.