Evidence map›Paper›PMID 31601574›Full record

ArticleAJNR. American journal of neuroradiology2019

Dose Reduction While Preserving Diagnostic Quality in Head CT: Advancing the Application of Iterative Reconstruction Using a Live Animal Model.

F D Raslau, E J Escott, J Smiley, C Adams, D Feigal, H Ganesh, C Wang, J Zhang

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In one paragraph

Article in AJNR. American journal of neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

F D RaslauFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.) flavius.raslau@uky.edu.ORCID 0000-0002-1228-1351
E J EscottFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.).ORCID 0000-0003-4166-0630
J SmileyLaboratory Animal Resources (J.S.).ORCID 0000-0002-0963-3379
C AdamsFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.).ORCID 0000-0002-8760-483X
D FeigalFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.).ORCID 0000-0001-5810-2278
H GaneshFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.).ORCID 0000-0002-7747-6942
C WangBiostatistics (C.W.), University of Kentucky, Lexington, Kentucky.ORCID 0000-0001-8984-4995
J ZhangFrom the Departments of Radiology (F.D.R., E.J.E., C.A., D.F., H.G., J.Z.).ORCID 0000-0003-2006-9964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIterative reconstruction has promise in lowering the radiation dose without compromising image quality, but its full potential has not yet been realized. While phantom studies cannot fully approximate the subjective effects on image quality, live animal models afford this assessment. We characterize dose reduction in head CT by applying advanced modeled iterative reconstruction (ADMIRE) in a live ovine model while evaluating preservation of gray-white matter detectability and image texture compared with filtered back-projection. MATERIALS AND

methodsA live sheep was scanned on a Force CT scanner (Siemens) at 12 dose levels (82-982 effective mAs). Images were reconstructed with filtered back-projection and ADMIRE (strengths, 1-5). A total of 72 combinations (12 doses × 6 reconstructions) were evaluated qualitatively for resemblance to the reference image (highest dose with filtered back-projection) using 2 metrics: detectability of gray-white matter differentiation and noise-versus-smoothness in image texture. Quantitative analysis for noise, SNR, and contrast-to-noise was also performed across all dose-strength combinations.

resultsBoth qualitative and quantitative results confirm that gray-white matter differentiation suffers at a lower dose but recovers when complemented by higher iterative reconstruction strength, and image texture acquires excessive smoothness with a higher iterative reconstruction strength but recovers when complemented by dose reduction. Image quality equivalent to the reference image is achieved by a 58% dose reduction with ADMIRE-5.

conclusionsAn approximately 60% dose reduction may be possible while preserving diagnostic quality with the appropriate dose-strength combination. This in vivo study can serve as a useful guide for translating the full implementation of iterative reconstruction in clinical practice.

Indexed as

BrainRadiation DosageAlgorithmsAnimalsDisease Models, AnimalFemaleHumansMaleNeuroimagingRadiographic Image Interpretation, Computer-AssistedSheepTomography, X-Ray Computed

Identifiers

PMID31601574
PMCPMC6975097

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.