ArticleCancer discovery2020
Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers.
Open access · greenAbstract read
In one paragraph
Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 138 citations in OpenAlex.
- Trial
- Deciphering the Genomic Landscape of Renal Cell Carcinoma Brain Metastases.bioRxiv : the preprint server for biology · 2026Article
- Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.Cell death & disease · 2026Article
- Decoding Brain Metastasis With Liquid Biopsy: Biomarkers and Technologies in EGFR-Mutant NSCLC.Cancer medicine · 2026Review
- Reconstructing the metastatic journey: functional circulating tumor cells and disseminated tumor cells based models for translational oncology.Journal of experimental & clinical cancer research : CR · 2026Review
- Breast cancer brain metastasis: from molecular insights to therapeutic innovation.Frontiers in immunology · 2026Review
- Targeting the tripartite axis of immune-metabolic-spatial crosstalk to overcome therapy resistance in breast cancer.Frontiers in immunology · 2026Review
- DNMT1 modulation of RASSF1A methylation enhances breast cancer brain metastasis.Cell death & disease · 2025Article
- Prediction of Lung Cancer Metastasis Risk Based on Single-Cell Metabolic Profiling of Circulating Tumor Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Computational ranking identifies Plexin-B2 in circulating tumor cell clustering with monocytes in breast cancer metastasis.Nature communications · 2025Article
- HIF-1 promotes murine breast cancer brain metastasis by increasing production of integrin β3-containing extracellular vesicles.The Journal of clinical investigation · 2025Article
- Single‑cell RNA sequencing reveals TMEM71 as an immunomodulatory biomarker predicting immune checkpoint blockade response in breast cancer.Discover oncology · 2025Article
- The epigenetic landscape of brain metastasis.Oncogene · 2025Review
- Liquid biopsies for the monitoring of gliomas and brain metastases in adults.Acta neuropathologica · 2025Review
- Harnessing exosomes for targeted drug delivery systems to combat brain cancer.Cancer cell international · 2025Review
- Molecular Underpinnings of Brain Metastases.International journal of molecular sciences · 2025Review
- Intratumour oxidative hotspots provide a niche for cancer cell dissemination.Nature cell biology · 2025Article
- Review
- Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy.Frontiers in immunology · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 2 institutions in 1 country.
Remi KlotzDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Amal Thomas *Department of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0003-4494-4487
Teng Teng *Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Sung Min HanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Oihana IriondoDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0002-7464-5026
Lin LiDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Sara Restrepo-VassalliBridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
Alan WangDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0001-9749-0082
Negeen IzadianDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Matthew MacKayDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Byoung-San MoonDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Kevin J LiuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0003-3836-3213
Sathish Kumar GanesanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0002-5161-9343
Grace LeeDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Diane S KangDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Charlotte S WalmsleyMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
Christopher PintoMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
Michael F PressUSC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Wange LuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Janice LuUSC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Dejan JuricMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
Aditya BardiaMassachusetts General Hospital Cancer Center, Boston, Massachusetts.
James HicksBridge Institute, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.ORCID https://orcid.org/0000-0001-5353-4338
Bodour SalhiaUSC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California.
Frank AttenelloNeurological Surgery, Keck School of Medicine of the University of California, Los Angeles, California.ORCID https://orcid.org/0000-0002-7218-8669
Andrew D SmithDepartment of Molecular and Computational Biology, USC David and Dana Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California.
Min YuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California. minyu@med.usc.edu.
University of Southern California · USMassachusetts General Hospital · US
Funding
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4MSouthern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3MSouthern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0MDOCTORAL AND POST-DOCTORAL TRAINING IN CRANIOFACIAL BIOLOGYT90DE021982 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAINE, MICHAEL LANSDELL · 2011 to 2025
$6.2MDeveloping Individualized Medicine Targeting Metastatic Breast Cancer Stem CellsDP2CA206653 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YU, MIN · 2015 to 2019
$2.6MNCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855NCI NIH HHS DP2 CA206653NCI NIH HHS P30 CA014089NIDCR NIH HHS T90 DE021982
Abstract
Hematogenous metastasis is initiated by a subset of circulating tumor cells (CTC) shed from primary or metastatic tumors into the blood circulation. Thus, CTCs provide a unique patient biopsy resource to decipher the cellular subpopulations that initiate metastasis and their molecular properties. However, one crucial question is whether CTCs derived and expanded
Indexed as
Tumor MicroenvironmentAnimalsAntigens, CDApoptosisBiomarkers, TumorBlood-Brain BarrierBrain NeoplasmsBreast NeoplasmsCell ProliferationFemaleGene Expression Regulation, NeoplasticGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansMiceMice, Inbred NODAntigens, CDBiomarkers, TumorCD100 antigenGlutathione PeroxidaseGlutathione Peroxidase GPX1MYC protein, humanProto-Oncogene Proteins c-mycSemaphorins
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