ArticleDevelopment (Cambridge, England)2019
N-cadherin stabilises neural identity by dampening anti-neural signals.
Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Dependence of cell fate potential and cadherin switching on the coordinate within the primitive streak during differentiation of human pluripotent stem cells.Development (Cambridge, England) · 2026Article
- Keeping up with the neighbours: local synchronisation of cell fate decisions during development.EMBO reports · 2026Review
- Mechanotransductive N-cadherin binding induces differentiation in human neural stem cells.Mechanobiology in medicine · 2025Article
- Templated Pluripotent Stem Cell Differentiation via Substratum-Guided Artificial Signaling.ACS biomaterials science & engineering · 2024Article
- An Extensive Study Regarding the Microscopic Anatomy of the Early Fetal Human Optic Nerve.Neurology international · 2024Article
- Single-cell RNA sequencing of mid-to-late stage spider embryos: new insights into spider development.BMC genomics · 2024Article
- Mutation of p53 increases the competitive ability of pluripotent stem cells.Development (Cambridge, England) · 2024Article
- Cell state transitions: catch them if you can.Development (Cambridge, England) · 2023Article
- Large-scale perfused tissues via synthetic 3D soft microfluidics.Nature communications · 2023Article
- Pathogenesis of neural tube defects: The regulation and disruption of cellular processes underlying neural tube closure.WIREs mechanisms of disease · 2022Review
- New developments in the biology of fibroblast growth factors.WIREs mechanisms of disease · 2022Review
- Cadherins in early neural development.Cellular and molecular life sciences : CMLS · 2021Review
- Inducible Stem-Cell-Derived Embryos Capture Mouse Morphogenetic Events In Vitro.Developmental cell · 2021Article
- Role of miRNA-mRNA Interaction in Neural Stem Cell Differentiation of Induced Pluripotent Stem Cells.International journal of molecular sciences · 2020Article
- Induction of fetal abnormalities and genotoxicity by molybdenum nanoparticles in pregnant female mice and fetuses.Environmental science and pollution research international · 2020Article
- A gastruloid model of the interaction between embryonic and extra-embryonic cell types.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use quantitative image analysis to show that N-cadherin promotes neural differentiation independently of its effects on cell cohesiveness. We reveal that cadherin switching diminishes the level of nuclear β-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate. Finally, we compare the timing of cadherin switching and differentiation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.