ArticleJournal of translational medicine2019
Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study.
Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 63 citations in OpenAlex.
- Opposing associations of muscle and fat mass changes on serum uric acid levels: a 2-year longitudinal cohort study.The Korean journal of internal medicine · 2026Article
- Uric Acid Induces Hepatocytes Ferroptosis Through HIF-2α/DMT1-Mediated Iron Overload.International journal of molecular sciences · 2026Article
- Correlation of skeletal muscle mass and visceral fat area with hyperuricemia in male adolescents.BMC endocrine disorders · 2026Article
- Article
- Distinct Characteristics of Patients with Gout and an Underweight or Normal Body Mass Index: A Single-Center Retrospective Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Estimated glucose disposal rate and risk of incident hyperuricemia: insights from CHARLS.Scientific reports · 2025Article
- Nonlinear association of cardiometabolic index with hyperuricemia: insights from the NHANES 1999-2018 study.Frontiers in endocrinology · 2025Article
- Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Identifying metabolic parameters as key indicators of hyperuricemia and ischemic stroke comorbidity via interpretable Clinlabomics models.Frontiers in endocrinology · 2025Article
- The association between visceral adipose accumulation and hyperuricemia risk among Chinese elder individuals: A nationwide prospective cohort study.Preventive medicine reports · 2024Article
- Predictive power of lipid-related indicators for testosterone deficiency: a comparative analysis, NHANES 2011-2016.International urology and nephrology · 2024Observational
- L-shaped association between lean body mass to visceral fat mass ratio with hyperuricemia: a cross-sectional study.Lipids in health and disease · 2024Article
- Association between anthropometric indices and hyperuricemia: a nationwide study in China.Clinical rheumatology · 2024Article
- Association between triglyceride glucose index and hyperuricemia: a new evidence from China and the United States.Frontiers in endocrinology · 2024Article
- Sex-specific differences in the associations between adiposity indices and incident hyperuricemia among middle-aged and older adults: a nationwide longitudinal study.Frontiers in endocrinology · 2024Article
- Exploring the Relationship Between Different Obesity Metabolism Indices and Hyperuricemia in Patients with Hypertension and Coronary Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Association between serum lipoprotein(a) and mildly reduced eGFR: a cross-sectional study.BMC nephrology · 2023Article
- Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI) and the risk of acute pancreatitis: a prospective study in adults of North China.Lipids in health and disease · 2023Article
- Blood Lead Level Is Associated with Visceral Adipose Dysfunction in Patients with Type 2 Diabetes.Biological trace element research · 2023Article
- Metabolically healthy obesity is associated with higher risk of both hyperfiltration and mildly reduced estimated glomerular filtration rate: the role of serum uric acid in a cross-sectional study.Journal of translational medicine · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
backgroundThe role of body fat distribution in uric acid metabolism is still ambiguity. We aimed to investigate the independent contribution of visceral adipose measured by visceral adiposity index and lipid accumulation product and liver fat assessed by fatty liver index to the risk of hyperuricemia.
methodsWe conducted a cross-sectional study involving 1284 participants aged ≥ 40 years old recruited from communities in Zhonglou district, Changzhou. Each participant completed a standard questionnaire, and provided blood samples for biochemical measurements. Visceral adiposity index, fatty liver index and lipid accumulation product were calculated by simple anthropometric and functional parameters. Hyperuricemia was defined as serum uric acid ≥ 420 μmol/l for males and ≥ 360 μmol/l for females.
resultsThe prevalence of hyperuricemia was 15.9% and gradually increased across tertiles of adiposity-based indices. The visceral adipose-based measurements (visceral adiposity index, fatty liver index, lipid accumulation product) had better power to discriminate hyperuricemia than body mass index (BMI), waist circumference and neck circumference, and visceral adiposity index exhibited the highest power, with the area under the receiver operating characteristics curve (AUROC) of 0.662 (0.636-0.688). Multivariate logistic regression found 1.49-fold, 2.21-fold and 2.12-fold increased risk of hyperuricemia with 1-unit increment of visceral adiposity index, fatty liver index, and lipid accumulation product, respectively. Compared to tertile 1, the odds ratios of hyperuricemia for the second tertile and the third tertile of visceral adiposity index were 1.57 (1.00-2.50) and 3.11 (1.96-4.94), those of fatty liver index were 1.64 (1.05-2.68) and 3.58 (1.94-6.01), and those of lipid accumulation product were 1.93 (1.19-3.15) and 3.53 (2.05-6.09), respectively. However, no significant associations of BMI, waist circumference and neck circumference with hyperuricemia were observed.
conclusionsVisceral adipose accumulation increased the risk of hyperuricemia, independently of BMI, waist circumference and neck circumference, among middle-aged and elderly Chinese adults.
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