ArticleBMC pediatrics2019
Prevalence, clinical outcomes and rainfall association of acute respiratory infection by human metapneumovirus in children in Bogotá, Colombia.
Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What are the risk factors for death among children with pneumonia in low- and middle-income countries? A systematic review.Journal of global health · 2023Pooled it
- Acute Respiratory Tract Infections and Severe Disease Among Hospitalized Children.JAMA network open · 2026Article
- Clinical characteristics, co-detection patterns and prognostic risk factors of human metapneumovirus infection in children: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Human Metapneumovirus Circulation and Seasonality on a Global Scale, 2016-2025: Changes in Patterns and Epidemic Timing in the Pre- Versus Post-COVID-19 Era.Influenza and other respiratory viruses · 2025Article
- High incidence of the virus among respiratory pathogens in children with lower respiratory tract infection in northwestern China.Journal of medical virology · 2023Article
- Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.Influenza and other respiratory viruses · 2022Article
- The Burden of Respiratory Viruses and Their Prevalence in Different Geographical Regions of India: 1970-2020.Frontiers in microbiology · 2021Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute respiratory infections (ARIs) are one of the main causes of morbidity and mortality in children. Viruses are the main etiological agents, and their behavior tends to be seasonal and vary by geographical location. Human metapneumovirus (HMPV) has recently been described as a cause of severe acute respiratory infection and its prevalence and clinical behavior in children at moderate altitudes is unknown.
methodsA cross-sectional study was carried out on patients seen at a university hospital in Bogotá, Colombia between October 2015 and December 2017 in a city at a moderate altitude above sea level. Children with acute respiratory infections who had had a multiplex RT-PCR assay were selected. The prevalence of HMPV infection, its clinical outcomes and its relationship to rainfall were evaluated.
resultsOut of a total of 14,760 discharged patients, multiplex RT-PCR was performed on 502 and a virus was detected in 420 children with acute respiratory infection (ARI). The study group had a median age of 21 months (IQR 7-60), with similar proportion of males and females (56.4 and 43.6% respectively) and 5.2% (CI 95 3.3-7.8%) prevalence of HMPV infection. The group with HMPV infection showed a greater frequency of viral coinfection (22.7% vs 14% P = 0.03) compared with ARI caused by other viruses. The rate of bacterial coinfection (P = 0.31), presence of comorbidities (p = 0.75), length of hospital stay (P = 0.42), need for mechanical ventilation (P = 0.75) and mortality (P = 0.22) were similar for HMPV and other viral infections. A moderate correlation was established between HMPV infection and rainfall peaks (Spearman's Rho 0.44 p = 0.02).
conclusionsHuman metapneumovirus was the fifth most frequently isolated virus in children with ARI, had similar clinical behavior and severity to other viruses but a higher rate of viral coinfection. Its peaks seem to correlate to rainy seasons.
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