Evidence map›Paper›PMID 31601175›Full record

ArticleBMC cancer2019

Intra-arterial EmboCept S® and DC Bead® effectively inhibit tumor growth of colorectal rat liver metastases.

Christian Ziemann, Jonas Roller, Markus M Malter, Kira Keller, Otto Kollmar, Matthias Glanemann, Michael D Menger, Jens Sperling

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christian ZiemannInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany. chr.ziemann@icloud.com.ORCID http://orcid.org/0000-0003-4114-0483
Jonas RollerInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Markus M MalterInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Kira KellerInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Otto KollmarInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Matthias GlanemannDepartment of General, Visceral, Vascular and Pediatric Surgery, Saarland University, Homburg/Saar, Germany.
Michael D MengerInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Jens SperlingInstitute for Clinical and Experimental Surgery, Saarland University, Homburg/Saar, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntra-arterial therapy with embolics is established for the treatment of malignancies of the liver. However, there are no studies comparing the different effects of various embolics used in clinical practice. Herein, we analyzed the effect of 3 different embolics on tumor growth in a rat model of colorectal liver metastases.

methodsEight days after subcapsular implantation of 5 × 10

resultsOn day 11 animals of the control group showed a tumor growth of ~ 60% compared to day 8. Application of Lipiodol Ultra-Fluid® did not significantly influence tumor growth (~ 40%). In contrast, treatment with EmboCept S® or DC Bead® completely inhibited tumor growth. Of interest, application of EmboCept S® did not only completely inhibit tumor growth but even decreased tumor size. Immunohistochemical analysis showed a significant increase of necrotic areas within the tumors after application of EmboCept S® and DC Bead® compared to Lipiodol® Ultra-Fluid.

conclusionThe present study demonstrates that an intra-arterial therapy with EmboCept S® and DC Bead®, but not Lipiodol® Ultra-Fluid, results in a complete inhibition of rat colorectal liver metastatic growth.

Indexed as

MicrospheresAnimalsAntineoplastic AgentsApoptosisCell Line, TumorCell ProliferationColonic NeoplasmsEthiodized OilFemaleHepatic ArteryHeterograftsInfusions, Intra-ArterialLiverLiver NeoplasmsMaleModels, AnimalAntineoplastic AgentsEthiodized OilPolyvinyl Alcoholpolyvinyl alcohol hydrogelStarchAngiogenesisColorectal liver metastasisDegradable starch microspheresIntra-arterial therapyNecrosis

Identifiers

PMID31601175
PMCPMC6785845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.