Evidence map›Paper›PMID 31601172›Full record

ArticleBMC genomics2019

Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci.

Nives Zimmermann, William J Gibbons, Shelli M Homan, Daniel R Prows

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Nives ZimmermannDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
William J GibbonsDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Bldg. R. MLC 7016, Cincinnati, OH, 45229-3039, USA.
Shelli M HomanDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Bldg. R. MLC 7016, Cincinnati, OH, 45229-3039, USA.
Daniel R ProwsDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. daniel.prows@cchmc.org.ORCID http://orcid.org/0000-0003-0049-148X
Cincinnati Children's Hospital Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
A Novel Mouse Model of Eosinophilic Vasculitis with Cardiac ComplicationsR21HL135507 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PROWS, DANIEL R, ZIMMERMANN, NIVES · 2017 to 2018
$429k
NHLBI NIH HHS HL135507NHLBI NIH HHS R21 HL135507NIEHS NIH HHS P30 ES006096NIEHS NIH HHS P30ES006096
6 · The paper itself

Abstract

backgroundHeart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our understanding of the pathophysiology of eosinophil-mediated diseases with heart complications is limited. We have discovered a mouse mutant, now maintained on an A/J inbred background, that spontaneously develops hypereosinophilia in multiple organs. Cellular infiltration into the heart causes an eosinophilic myocarditis, with affected mice of the mutant line (i.e., A/J

resultsMaintaining the A/J

conclusionsThese results indicate the HD trait in this mutant mouse model of eosinophilic myocarditis is oligogenic with variable penetrance, due to multiple segregating variants and possibly additional genetic or nongenetic factors. The A/J

Indexed as

MutationAnimalsChromosome MappingChromosomes, MammalianDisease Models, AnimalEosinophiliaFemaleGenetic LinkageGenetic LociMaleMiceMice, Inbred C57BLMice, Inbred StrainsMyocarditisPenetranceChurg-Strauss SyndromeDilated cardiomyopathyDisease modelEosinophil-associated diseaseHeart failureHypereosinophiliaLinkage mappingOligogenic traitQTLSpontaneous mouse mutant

Identifiers

PMID31601172
PMCPMC6788080
OpenAlexW2979542071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.