ArticleRNA biology2021
The LARP1 La-Module recognizes both ends of TOP mRNAs.
Article in RNA biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- The role ofFrontiers in endocrinology · 2026Article
- The RNA-binding protein PRRC2B preserves 5' TOP mRNA during starvation to maintain ribosome biogenesis during nutrient recovery.Nucleic acids research · 2025Article
- RNMT-dependent RNA cap methylation in health and disease.The Biochemical journal · 2025Review
- A Robust Expression and Purification Protocol for the Production of the La Domain of Human LARP6.ACS omega · 2025Article
- LARP1 binds ribosomes and TOP mRNAs in repressed complexes.The EMBO journal · 2024Article
- Article
- Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5'TOP mRNAs.Science advances · 2024Article
- Enhanced binding of guanylated poly(A) RNA by the LaM domain of LARP1.RNA biology · 2024Article
- Construction of hub transcription factor-microRNAs-messenger RNA regulatory network in recurrent implantation failure.Journal of assisted reproduction and genetics · 2024Article
- LARP1 senses free ribosomes to coordinate supply and demand of ribosomal proteins.bioRxiv : the preprint server for biology · 2023Article
- Article
- Article
- Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation.Nucleic acids research · 2021Article
- mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.Nucleic acids research · 2021Article
- Controversies around the function of LARP1.RNA biology · 2021Review
- Review
- The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.RNA biology · 2021Article
- LARP1 and LARP4: up close with PABP for mRNA 3' poly(A) protection and stabilization.RNA biology · 2021Review
- The mTOR regulated RNA-binding protein LARP1 requires PABPC1 for guided mRNA interaction.Nucleic acids research · 2021Article
- Subcellular mRNA Localization Regulates Ribosome Biogenesis in Migrating Cells.Developmental cell · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
La-Related Protein 1 (LARP1) is an RNA-binding protein that regulates the stability and translation of mRNAs encoding the translation machinery, including ribosomal proteins and translation factors. These mRNAs are characterized by a 5'-terminal oligopyrimidine (TOP) motif that coordinates their temporal and stoichiometric expression. While LARP1 represses TOP mRNA translation
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.