ArticleThe Journal of international medical research2020
Computed tomography-guided biopsy of small lung nodules: diagnostic accuracy and analysis for true negatives.
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Low-dose versus standard-dose computed tomography-guided biopsy for pulmonary nodules: a randomized controlled trial.Journal of cardiothoracic surgery · 2023Trial
- Machine learning predicts severe adverse events and salvage success of CT-guided lung biopsy after nondiagnostic transbronchial lung biopsy.European radiology · 2026Article
- Computed tomography-guided percutaneous biopsy for diagnosing pulmonary nodules: a prospective, multicenter observational study.Journal of thoracic disease · 2025Article
- Normal saline injection and rapid rollover; preventive effect on incidence of pneumothorax after CT-guided lung biopsy: a retrospective cohort study.BMC pulmonary medicine · 2024Article
- Machine-Learning-Based Classification Model to Address Diagnostic Challenges in Transbronchial Lung Biopsy.Cancers · 2024Article
- Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign.World journal of surgical oncology · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
objectiveWe evaluated the diagnostic accuracy of computed tomography (CT)-guided transthoracic core needle biopsy (TCNB) for small (≤20-mm) lung nodules and identified predictive factors for true negatives among benign biopsy results.
methodsFrom March 2010 to June 2015, 222 patients with small lung nodules underwent CT-guided TCNB. We retrospectively analysed data regarding technical success, diagnostic accuracy, and predictors of true negatives.
resultsThe technical success rate was 100%. The TCNB results of the 222 lung nodules included malignancy (n = 136), suspected malignancy (n = 8), specific benign lesion (n = 17), and nonspecific benign lesion (n = 61). The final diagnosis of 222 lung nodules included malignant (n = 160), benign (n = 60), and nondiagnostic lesions (n = 2). The sensitivity, specificity, and overall diagnostic accuracy of CT-guided TCNB for small lung nodules were 90.0%, 100%, and 92.7%, respectively. Pneumothorax and haemoptysis occurred in 23 and 41 patients, respectively. Based on the Cox regression analysis, the significant independent predictive factor for true negatives was a biopsy result of chronic inflammation with fibroplasia.
conclusionsCT-guided TCNB offers high diagnostic accuracy for small lung nodules, and a biopsy result of chronic inflammation with fibroplasia can predict a true-negative result.
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