ArticleCancers2019
A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth.
Open access · goldAbstract read
In one paragraph
Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors.Drug delivery and translational research · 2026Article
- Article
- Phytochemicals for Hair Health Targeting Growth Signaling Molecules in Hair Follicular Stem Cells: A New Strategy for Hair Growth.Journal of microbiology and biotechnology · 2025Review
- G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers.MedComm · 2025Review
- Glioma stem cells: drivers of tumor progression and recurrence.Stem cell research & therapy · 2025Review
- Hedgehog Pathway Inhibition by Novel Small Molecules Impairs Melanoma Cell Migration and Invasion under Hypoxia.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma.Nature communications · 2024Article
- Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins.PloS one · 2024Article
- Hedgehog pathway in sarcoma: from preclinical mechanism to clinical application.Journal of cancer research and clinical oncology · 2023Review
- Keratin19 promotes pancreatic cancer progression and poor prognosis via activating the Hedgehog pathway.International journal of oncology · 2023Article
- Targeting the Hedgehog Pathway in Rhabdomyosarcoma.Cancers · 2023Review
- Analysis of Primary Cilium Expression and Hedgehog Pathway Activation in Mesothelioma Throws Back Its Complex Biology.Cancers · 2022Article
- Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia.Cancers · 2022Article
- Modulation of Hedgehog Signaling for the Treatment of Basal Cell Carcinoma and the Development of Preclinical Models.Biomedicines · 2022Review
- STAT3 is required for Smo-dependent signaling and mediates Smo-targeted treatment resistance and tumorigenesis in Shh medulloblastoma.Molecular oncology · 2022Article
- The Triprenylated Anthranoid Ferruginin A, a Promising Scaffold for the Development of Novel Antibiotics against Gram-Positive Bacteria.Antibiotics (Basel, Switzerland) · 2022Article
- Identification of solamargine as a cisplatin sensitizer through phenotypical screening in cisplatin-resistant NSCLC organoids.Frontiers in pharmacology · 2022Article
- Molecular Mechanisms Involving the Sonic Hedgehog Pathway in Lung Cancer Therapy: Recent Advances.Frontiers in oncology · 2022Review
- Exploring the Assembly of Resorc[4]arenes for the Construction of Supramolecular Nano-Aggregates.International journal of molecular sciences · 2021Article
- Identification of Effective Anticancer G-Quadruplex-Targeting Chemotypes through the Exploration of a High Diversity Library of Natural Compounds.Pharmaceutics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Ludovica Lospinoso SeveriniDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. ludovica.lospinososeverini@uniroma1.it.
Deborah QuaglioDepartment of Chemistry and Technology of Drugs, Sapienza University, Piazzale A. Moro 5, 00161 Rome, Italy. deborah.quaglio@uniroma1.it.
Irene BasiliDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. irenebasili.ib@gmail.com.
Francesca GhirgaCLNS@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy. francesca.ghirga@iit.it.
Francesca BufalieriDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. francesca.bufalieri@uniroma1.it.
Miriam CaimanoDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. miriam.caimano@uniroma1.it.
Silvia BalducciDepartment of Chemistry and Technology of Drugs, Sapienza University, Piazzale A. Moro 5, 00161 Rome, Italy. silvia.balducci@uniroma1.it.
Marta MorettiDepartment of Experimental Medicine, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy. marta.moretti@uniroma1.it.
Isabella RomeoDepartment of Chemistry and Technology of Drugs, Sapienza University, Piazzale A. Moro 5, 00161 Rome, Italy. isabella.romeo1988@gmail.com.
Elena LoricchioDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. elena.loricchio@uniroma1.it.
Marella MaroderDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. marella.maroder@uniroma1.it.
Bruno BottaDepartment of Chemistry and Technology of Drugs, Sapienza University, Piazzale A. Moro 5, 00161 Rome, Italy. bruno.botta@uniroma1.it.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, via Aldo Moro 2, 53100 Siena, Italy. mattia.mori@unisi.it.
Paola InfanteCLNS@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy. paola.infante@iit.it.
Lucia Di MarcotullioDepartment of Molecular Medicine, Sapienza University, Viale Regina Elena 291, 00161 Rome, Italy. lucia.dimarcotullio@uniroma1.it.
Sapienza University of Rome · ITItalian Institute of Technology · ITIstituto Pasteur · ITUniversity of Siena · IT
Funding
Associazione Italiana per la Ricerca sul Cancro IG20801Istituto Pasteur-Fondazione Cenci Bolognetti Di Marcotullio call 2019Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2012C5YJSK002Ministero dell'Istruzione, dell'Università e della Ricerca PRIN 2017BF3PXZ003
Abstract
PubMed holds no abstract for this paper.
Indexed as
cancerGli1HedgehogmultitargetSmo
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.