ArticleToxins2019
Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake,
Article in Toxins, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Venom Variation as a Window into the Ecology and Evolution of Snakes.Integrative and comparative biology · 2026Review
- The green lacewing venom system and the complex mechanisms underlying its evolution.Molecular biology and evolution · 2026Article
- Transcriptomic Insights Into the Evolution of Snake Venom: Mechanisms, Diversity, and Adaptation.Scientifica · 2026Review
- Article
- Molecular Mechanisms of Venom Diversity.Toxins · 2025Review
- Isolation, characterization, and expression of theResearch in pharmaceutical sciences · 2025Article
- A Vision for VenomsBase: An Integrated Knowledgebase for the Study of Venoms and Their Applications.Integrative organismal biology (Oxford, England) · 2025Article
- Integrative multi-omics analysis reveals the contribution of neoVTX genes to venom diversity of Synanceia verrucosa.BMC genomics · 2024Article
- Review
- Towards the Exploration and Evolution of Insulin-like Venoms in Actiniaria (Marine drugs · 2024Review
- Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity.Genome research · 2023Article
- A Metalloproteinase Cocktail from the Venom ofToxins · 2023Article
- Article
- Highly Evolvable: Investigating Interspecific and Intraspecific Venom Variation in Taipans (Toxins · 2023Article
- Article
- Article
- The rise of genomics in snake venom research: recent advances and future perspectives.GigaScience · 2022Article
- Exploring the five-paced viper (The journal of venomous animals and toxins including tropical diseases · 2021Article
- Focused Proteomics Analysis of Habu Snake (Frontiers in pharmacology · 2021Article
- Causes and Consequences of Snake Venom Variation.Trends in pharmacological sciences · 2020Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Snake venoms are complex mixtures of toxic proteins encoded by various gene families that function synergistically to incapacitate prey. A huge repertoire of snake venom genes and proteins have been reported, and alternative splicing is suggested to be involved in the production of divergent gene transcripts. However, a genome-wide survey of the transcript repertoire and the extent of alternative splicing still remains to be determined. In this study, the comprehensive analysis of transcriptomes in the venom gland was achieved by using PacBio sequencing. Extensive alternative splicing was observed in three venom protein gene families, metalloproteinase (MP), serine protease (SP), and vascular endothelial growth factors (VEGF). Eleven MP and SP genes and a VEGF gene are expressed as a total of 81, 61, and 8 transcript variants, respectively. In the MP gene family, individual genes are transcribed into different classes of MPs by alternative splicing. We also observed trans-splicing among the clustered SP genes. No other venom genes as well as non-venom counterpart genes exhibited alternative splicing. Our results thus indicate a potential contribution of mRNA alternative and trans-splicing in the production of highly variable transcripts of venom genes in the habu snake.
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