Evidence map›Paper›PMID 31600955›Full record

ArticleAntioxidants (Basel, Switzerland)2019

Adenosine Derivates as Antioxidant Agents: Synthesis, Characterization, in Vitro Activity, and Theoretical Insights.

Francisco Valdes, Nelson Brown, Alejandro Morales-Bayuelo, Luis Prent-Peñaloza, Margarita Gutierrez

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Francisco ValdesOrganic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), PhD Sciences Mention Investigation and Development of Bioactive Products, Institute of Chemistry of Natural Resources, Universidad de Talca, Casilla 747, Talca 3460000, Chile. franciscovaldesz@hotmail.es.
Nelson BrownCenter for Medical Research, University of Talca School of Medicine, Talca 3460000, Chile. nbrown@utalca.cl.
Alejandro Morales-BayueloCentro de Investigación de Procesos del Tecnológico Comfenalco (CIPTEC), Programa de Ingeniería Industrial, Fundación Universitaria Tecnológico Comfenalco-Cartagena, Cr 44 D N 30A, 91, Cartagena-Bolívar 130001, Colombia. alejandromoraba@hotmail.com.
Luis Prent-PeñalozaOrganic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), PhD Applied Sciences, Faculty of Engineering and Institute of Chemistry of Natural Resources, Universidad de Talca, Casilla 747, Talca 3460000, Chile. luisprent@gmail.com.
Margarita GutierrezOrganic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), PhD Sciences Mention Investigation and Development of Bioactive Products, Institute of Chemistry of Natural Resources, Universidad de Talca, Casilla 747, Talca 3460000, Chile. mgutierrez@utalca.cl.
University of Talca · CLFundación Universitaria Tecnológico Comfenalco Cartagena · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this work, we present results about the synthesis and the antioxidant properties of seven adenosine derivatives. Four of these compounds were synthesized by substituting the N6-position of adenosine with aliphatic amines, and three were obtained by modification of the ribose ring. All compounds were obtained in pure form using column chromatography, and their structures were elucidated by infrared spectroscopy (IR) and Nuclear Magnetic Resonance (NMR). All adenosine derivatives were further evaluated in vitro as free radical scavengers. Our results show that compounds

Indexed as

adenosine derivativesantioxidantchemical reactivity indexdensity functional theory (DFT)Molecular Quantum Similarity indexscavenger

Identifiers

PMID31600955
PMCPMC6826950
OpenAlexW2980034370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.