ArticleMolecules (Basel, Switzerland)2019
Determination of Antidepressants and Antipsychotics in Dried Blood Spots (DBSs) Collected from Post-Mortem Samples and Evaluation of the Stability over a Three-Month Period.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 46 citations in OpenAlex.
- UHPLC-MS/MS for Antipsychotic Drug Monitoring: A Systematic Review of Clinical and Analytical Performance.Journal of clinical medicine · 2025Review
- Article
- Identification of Benzodiazepine Use Based on Dried Blood Stains Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Direct Immersion-Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders.Molecules (Basel, Switzerland) · 2024Article
- Forensic Aspects of a Fatal Intoxication Involving Acetaminophen, Citalopram and Trazodone: A Case Report.Toxics · 2022Article
- New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Analysis of Cannabinoids and Metabolites in Dried Urine Spots (DUS).Molecules (Basel, Switzerland) · 2021Article
- Dried Blood Spot in Laboratory: Directions and Prospects.Diagnostics (Basel, Switzerland) · 2020Review
- Blood and Plasma Volumetric Absorptive Microsampling (VAMS) Coupled to LC-MS/MS for the Forensic Assessment of Cocaine Consumption.Molecules (Basel, Switzerland) · 2020Article
- Validated DBS method for filgotinib quantitation in rat dried blood spots and its application to a pharmacokinetic study in rats.ADMET & DMPK · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
An LC-MS/MS method for the identification and quantification of antidepressants and antipsychotics was developed on dried blood spots (DBSs). Moreover, analyte stability on DBSs within a 3-month period was monitored. Aliquots of 85 µL of blood from autopsy cases were pipetted onto DBS cards, which were dried and stored at room temperature. DBSs were analyzed in triplicate immediately, within the following 3 weeks, and after 3 months. For each analysis, a whole blood stain was extracted in phosphate buffer and purified using Solid Phase Extraction (SPE) cartridges in order to avoid matrix effects and injected in the LC-MS/MS system. Thirty-nine molecules were screened. Limits of detection (LODs) ranged between 0.1 and 3.2 ng/mL (g) and 0.1 and 5.2 ng/mL (g) for antidepressants and antipsychotics, respectively. Limits of quantification (LOQs) varied from 5 to 10.0 ng/mL for both. Sixteen cases among the 60 analyzed resulted positive for 17 different analytes; for 14 of these the method was fully validated. A general good agreement between the concentrations on DBSs and those measured in conventional blood samples (collected concurrently and stored at -20 °C) was observed. The degradation/enhancement percentage for most of the substances was lower than 20% within the 3-month period. Our results, obtained from real post-mortem cases, suggest that DBSs can be used for routine sample storage.
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