ArticleAntioxidants (Basel, Switzerland)2019
Oxidative Stress, NF-κB-Mediated Inflammation and Apoptosis in the Testes of Streptozotocin-Induced Diabetic Rats: Combined Protective Effects of Malaysian Propolis and Metformin.
Article in Antioxidants (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- A systematic review on the role of melatonin and its mechanisms on diabetes-related reproductive impairment in non-clinical studies.Frontiers in endocrinology · 2022Pooled it
- Spexin Attenuates Cerebral Ischemia-Reperfusion-Induced Brain Injury in Rats via Suppression of NF-κB-Associated Inflammation and Apoptosis.Molecular neurobiology · 2026Article
- Phthalate induced testicular degeneration in mice: biochemical, histopathological and immunohistochemical evidence for the interplay of oxidative stress, caspase-3, and NF-κB signaling.Scientific reports · 2026Article
- Anti-diabetic potential of Artemisia monosperma Delile extract related to anti-inflammatory, antioxidant, and wound-healing properties.Scientific reports · 2026Article
- Vitamin E fails to prevent bisphenol S induced testicular damage in diabetic rats.Scientific reports · 2026Article
- Effect of Hydroxytyrosol on OTULIN Levels in Testıcular Tıssue in Experımental Dıabetes Model Induced wıth Streptozotocin.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Zeaxanthin pretreatment alleviates low-temperature stress-induced injury in flue-cured tobacco seedlings by modulating the xanthophyll cycle and photoprotection.Frontiers in plant science · 2026Article
- Metformin mitigates oxidative stress and prevents apoptosis by modulating the Nrf2/HO-1 signaling pathway in a rat model of testicular ischemia/reperfusion.Iranian journal of basic medical sciences · 2026Article
- Taurine attenuates polystyrene microplastic-associated oxidative stress, inflammation, and apoptotic changes in the spleen of mice.Frontiers in pharmacology · 2026Article
- Therapeutic potential of heat-killed Lactobacillus reuteri against bile acid-induced male reproductive toxicity.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Effects of Apilarnil on Type 2 Diabetes-Induced IRS-1/PI3K/Akt Mediated Insulin Resistance in Male Rats.ACS omega · 2025Article
- Protective effects of berberine against diabetes-associated cognitive decline in mice.Acta diabetologica · 2025Article
- Protective effects of corn silk andToxicology research · 2025Article
- Potential Role of High-Intensity Interval Training-Induced Increase in Humanin Levels for the Management of Type 2 Diabetes.Journal of cellular and molecular medicine · 2025Article
- Review
- Chemical composition and pharmacological aspects of Malaysian stingless bee propolis: An up‑to‑date systematic review.Biomedical reports · 2025Article
- Propolis extract nanoparticles alleviate diabetes-induced reproductive dysfunction in male rats: antidiabetic, antioxidant, and steroidogenesis modulatory role.Scientific reports · 2024Article
- Article
- Wound Healing, Anti-Inflammatory and Anti-Oxidant Activities, and Chemical Composition of Korean Propolis from Different Sources.International journal of molecular sciences · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 3 countries.
Funding
Abstract
Oxidative stress, inflammation and apoptosis are major complications that trigger organ failure in diabetes mellitus (DM), and are proven to adversely affect the male reproductive system. Clinical and experimental studies have demonstrated the promising protective effects of propolis in DM and its associated systemic effects. Herein, we investigated the effect of Malaysian propolis (MP) on testicular oxidative stress, inflammation and apoptosis in diabetic rats. Further, the possibility of a complementary effect of MP with the anti-hyperglycaemic agent, metformin (Met), was studied with the idea of recommending its use in the event that Met alone is unable to contain the negative effects of DM on the male reproductive system in mind. Male Sprague-Dawley rats were either gavaged distilled water (normoglycaemic control and diabetic control groups), MP (diabetic rats on MP), Met (diabetic rats on Met) or MP+Met (diabetic rats on MP+Met), for 4 weeks. MP decreased oxidative stress by up-regulating (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.