ReviewMicroorganisms2019
Periodontal Pathogens as Risk Factors of Cardiovascular Diseases, Diabetes, Rheumatoid Arthritis, Cancer, and Chronic Obstructive Pulmonary Disease-Is There Cause for Consideration?
Review in Microorganisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06701058 (Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer), which is not on this map. Cited by 128 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer
Who cites it
128 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Breaking the silos: a systematic review of oral health integration strategies for improved oral health and cardiovascular outcomes.Frontiers in public health · 2026Pooled it
- Pooled it
- Pooled it
- Association of Chronic Obstructive Pulmonary Disease With Arrhythmia Risks: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Periodontal Disease and Age-Related Macular Degeneration: A Meta-Analysis of 112,240 Participants.BioMed research international · 2020Pooled it
- Article
- Association between periodontitis and heart failure: Mechanisms and clinical implications (Review).Molecular medicine reports · 2026Review
- Lifestyle Characteristics and Dietary Habits in Romanian Patients with Periodontitis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- The Gut-Reproduction-Oral-Immune Axis: Microbial Dysbiosis as a Shared Driver in Polycystic Ovary Syndrome and Endometriosis.Current microbiology · 2026Review
- Periodontal Disease and Its Association withMicroorganisms · 2026Review
- Periodontitis and respiratory infections - exploring the oral-systemic link.Annals of medicine and surgery (2012) · 2026Article
- Review
- Periodontitis pathogen Porphyromonas gingivalis promotes chronic obstructive pulmonary disease via affecting neutrophils chemotaxis and function.International journal of oral science · 2026Article
- Effect of periodontal therapy on the oral microbiome and lung function: an intervention study.Frontiers in cellular and infection microbiology · 2026Article
- Malignancy risk in patients with rheumatoid arthritis initiating biological or targeted synthetic disease-modifying antirheumatic drugs: a 5-year population-based cohort study.Therapeutic advances in musculoskeletal disease · 2026Article
- Akkermansia muciniphila Alleviates Porphyromonas gingivalis-induced Periodontal Disease by Enhancing Bacterial Clearance.Probiotics and antimicrobial proteins · 2026Article
- Planetary health diet with einkorn as a potential preventive strategy to improve interdental microbiota, oral health and quality of life: a pilot clinical trial.Journal of oral microbiology · 2026Article
- Effects of Long-Term Heavy Metal Exposure on Oral Microbial Antibiotic Resistance Genes of Residents in the Mining and Smelting Area.Microorganisms · 2025Article
- Effectiveness of Different Methods of Interdental Hygiene in Daily Practice Among Young Adults: Protocol for a Randomized, Single-Blind Controlled Trial.JMIR research protocols · 2025Article
- Unraveling the oral microbiome's role in Alzheimer's disease: From pathophysiology to therapeutic potential.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases, chronic obstructive pulmonary diseases, diabetes, rheumatoid arthritis, and cancer are the most common noncommunicable diseases (NCDs). These NCDs share risk factors with periodontal disease (PD), a preventable risk factor linked to lifestyle. The discussion regarding the association between these chronic diseases is more complex. There is still a significant knowledge gap particularly of the causal relationship between PD and NCDs. In this paper, we present fundamental knowledge of the mechanisms and roles of putative periodontal bacteria to gather several hypotheses, evidence that clinical studies thus far have not produced. Although the causal hypotheses are not yet clearly established on a biological basis, prevention and prophylactic measures are recommended to prevent even the possibility of such potential risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.