Evidence map›Paper›PMID 31600840›Full record

ArticleClinical genetics2020

Patterns and predictors of genetic referral among ovarian cancer patients at a National Cancer Institute-Comprehensive Cancer Center.

Adrianne R Mallen, Claire C Conley, Mary K Townsend, Ali Wells, Bernadette M Boac, Sarah Todd, Anjalika Gandhi, Michelle Kuznicki, Bianca M Augusto, McKenzie McIntyre and 4 more

Open access · greenAbstract read
In one paragraph

Article in Clinical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Predictive Genetic Testing in the Cancer Management and Prevention.Journal of cancer science and clinical therapeutics · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Adrianne R MallenDepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-3790-878X
Claire C ConleyDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0001-7695-2428
Mary K TownsendDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Ali WellsUniversity of South Florida, Morsani School of Medicine, Tampa, Florida.
Bernadette M BoacDepartment of Pathology, University of South Florida & Moffitt Cancer Center, Tampa, Florida.
Sarah ToddDepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, Florida.
Anjalika GandhiDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, Florida.
Michelle KuznickiDepartment of Obstetrics and Gynecology, University of South Florida, Tampa, Florida.
Bianca M AugustoDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-4556-530X
McKenzie McIntyreDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.
Brooke L FridleyDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida.
Shelley S TworogerDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-6986-7046
Robert M WenhamDepartment of Gynecologic Oncology, Moffitt Cancer Center, Tampa, Florida.
Susan T VadaparampilDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida.ORCID 0000-0002-1052-6917
Moffitt Cancer Center · USUniversity of South Florida · US

Funding

Behavioral Oncology Education & Career DevelopmentR25CA090314 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI BRANDON, THOMAS H · 2003 to 2018
$4.0M
Behavioral Oncology Education & Career DevelopmentT32CA090314 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Vani N Simmons, SUSAN T VADAPARAMPIL · 2019 to 2026
$2.9M
NCI NIH HHS R25 CA090314NCI NIH HHS T32 CA090314
6 · The paper itself

Abstract

Germline mutations (eg, BRCA1/2) have prognostic and treatment implications for ovarian cancer (OVCA) patients. Thus, national guidelines recommend genetic testing for OVCA patients. The present study examines patterns and predictors of genetics referral in OVCA patients. Electronic medical record data were abstracted retrospectively from 557 OVCA patients treated from 1 January 2001 to 31 December 2015. Logistic regression models identified sociodemographic characteristics, disease/treatment characteristics, family history data, provider characteristics, and survival data that predicted genetics referral. Overall, 27.5% of patients received referral. Eleven variables predicting referral were selected during stepwise regression: younger age, White race, not having private insurance, professional school education, year of OVCA diagnosis, platinum sensitivity, female gynecologic oncologist, chemotherapy administered by a gynecologic oncologist, clinical trial enrollment, longer overall survival, and family history of OVCA. Genetics referral among OVCA patients was similar to rates reported nationwide. Unique predictive factors will contribute to quality improvement and should be validated at a multi-institutional level to ensure guideline concordant care is provided to all OVCA patients. Future research should identify both patient-level and provider-level factors associated with genetics referral.

Indexed as

Genetic Predisposition to DiseaseAdultAgedAged, 80 and overBRCA1 ProteinBRCA2 ProteinDemographyFemaleGenetic TestingHealth PersonnelHumansInsurance CarriersLogistic ModelsMiddle AgedNational Cancer Institute (U.S.)Ovarian NeoplasmsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanBRCA1/2genetic counselinggenetic testinggermline mutationovarian cancer

Identifiers

PMID31600840
PMCPMC7322721
OpenAlexW2980309150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.