ArticleAmerican journal of perinatology2020
Relationship between Duration of Infant Exposure to a Moderate-to-Large Patent Ductus Arteriosus Shunt and the Risk of Developing Bronchopulmonary Dysplasia or Death Before 36 Weeks.
Article in American journal of perinatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Patent Ductus Arteriosus and Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension: A Bayesian Meta-Analysis.JAMA network open · 2023Pooled it
- Comparison of two targeted rescue treatments after the first week of expectant managment for very preterm infants with hemodynamically significant patent ductus arteriosus: a prospective study.Italian journal of pediatrics · 2026Trial
- Paracetamol or ibuprofen? A pilot study comparing rescue therapy for PDA in preterm infants within the first month.Frontiers in pediatrics · 2025Trial
- Trial
- Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial.The Journal of pediatrics · 2021Trial
- Respiratory support duration and the association between patent ductus arteriosus exposure and bronchopulmonary dysplasia.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- [Evolution of treatment strategies and risk-stratified management of patent ductus arteriosus in preterm infants].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Time-Series Machine Learning for Prediction of Bronchopulmonary Dysplasia.The Journal of pediatrics · 2026Article
- [Efficacy and safety of ibuprofen for the treatment of patent ductus arteriosus in preterm infants of different postnatal ages].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Trends in bronchopulmonary dysplasia and 15-year evolution in respiratory and hemodynamic management of very premature infants.Scientific reports · 2025Observational
- Predictive model of ibuprofen treatment failure in very preterm infants with patent ductus arteriosus using machine learning techniques.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- The pathogenesis of bronchopulmonary dysplasia: "It is never the heart, it is always the lung" - myth or maxim?Breathe (Sheffield, England) · 2025Review
- Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants.JAMA network open · 2025Article
- The Effect on Extubation of Early vs. Late Definitive Closure of the Patent Ductus Arteriosus in Premature Infants: A Target Trial Emulation Using Electronic Health Records.Journal of clinical medicine · 2025Article
- Patent ductus arteriosus and the association between lung ultrasound score and bronchopulmonary dysplasia: a secondary analysis of a prospective study.European journal of pediatrics · 2024Article
- Association between patent ductus arteriosus flow and home oxygen therapy in extremely preterm infants.Pediatric research · 2024Article
- Risk factors for severe bronchopulmonary dysplasia in a Chinese cohort of very preterm infants.Saudi medical journal · 2024Article
- Combined gestational age and serum fucose for early prediction of risk for bronchopulmonary dysplasia in premature infants.BMC pediatrics · 2024Article
- Should we "eliminate" PDA shunt in preterm infants? A narrative review.Frontiers in pediatrics · 2024Review
- Experiences in Patent Ductus Arteriosus Closure of Preterm Infants Transported to Another Center for Surgical Ligation.Turkish archives of pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveThis study was aimed to examine the relationship between duration of infant exposure to a moderate-to-large patent ductus arteriosus (PDA) shunt and the risk of developing bronchopulmonary dysplasia (BPD) or death before 36 weeks (BPD/death). STUDY
designInfants <28 weeks' gestation who survived ≥7 days (
resultsIn multivariable regression models, BPD/death did not appear to be increased until infants had been exposed to a moderate-to-large PDA for at least 7-13 days: OR (95%CI) (referent = closed or small PDA): moderate-to-large PDA exposure for <7 days: 0.38 (range, 0.10-1.46); for 7 to 13 days = 2.12 (range, 1.04-4.32); for ≥14 days = 3.86 (range, 2.15-6.96). Once the threshold of 7 to 13 days had been reached, additional exposure (≥14 days) did not significantly add to the increased incidence of BPD/death: (referent exposure = 7-13 days) exposure for 14 to 27 days = 1.34 (range, 0.52-3.45); for 28 to 48 days = 2.34 (range, 0.88-6.19); for ≥49 days = 1.80 (range. 0.59-5.47). A similar relationship was found for the outcome of BPD-alone.
conclusionInfants < 28 weeks' gestation required at least 7 to 13 days of exposure to a moderate-to-large PDA before a significant increase in the incidence of BPD/death was apparent. Once this threshold was reached additional exposure to a moderate-to-large PDA did not significantly add to the increased incidence of BPD/death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.