ArticleEuropean journal of radiology2019
Dual energy computed tomography analysis in cancer patients: What factors affect iodine concentration in contrast enhanced studies?
Article in European journal of radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Relative and normalized iodine concentrations derived from photon counting computed tomography and their correlation with tumor grade and Ki67 in pancreatic neuroendocrine neoplasia: A pilot study.Journal of neuroendocrinology · 2026Article
- Photon-counting versus energy-integrating CT of abdomen-pelvis: a phantom study on the potential for reducing iodine contrast media.European radiology experimental · 2025Article
- The hemodynamics of adrenal veins with four-dimensional computed tomography using quantitative time-density curve: a study based on aldosteronism patients.Scientific reports · 2023Review
- Physiological iodine uptake of the spine's bone marrow in dual-energy computed tomography - using artificial intelligence to define reference values based on 678 CT examinations of 189 individuals.Frontiers in endocrinology · 2023Article
- Deep Learning and Domain-Specific Knowledge to Segment the Liver from Synthetic Dual Energy CT Iodine Scans.Diagnostics (Basel, Switzerland) · 2022Article
- Initial experience with dual-layer detector spectral CT for diagnosis of blood or contrast after endovascular treatment for ischemic stroke.Neuroradiology · 2022Article
- Dual-Energy Computed Tomography of the Liver: Uses in Clinical Practices and Applications.Diagnostics (Basel, Switzerland) · 2021Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe aim of the study is to explore the patient's and scan's parameters that affect the iodine concentration in the abdomen using dual energy computed tomography (DECT) in an oncologic population.
methodThis is a retrospective study with consecutive patients with different cancers who underwent a single-source DECT (ssDECT) examinations at our institution between years 2015 and 2017. On axial IODINE images, the radiologist manually drew a circular ROI along the inner contour of the aorta. Mean iodine concentration and ROI areas were recorded. Body mass index for every patient was recorded. Descriptive statistics were summarized for iodine concentration and patient/scan characteristics. Linear regression was used to examine associations between iodine concentration in aorta and studied characteristics. Statistical significance was set at a p value < 0.05.
resultsThe univariate analysis, showed a statistically significant association between iodine concentration within the aorta and the area of ROI (Estimated Coefficient β: -0.013), the rate of injection (Estimated Coefficient β: 2.09), the acquisition time (Estimated Coefficient β: -0.195). In multivariable analysis iodine concentration in the aorta increased with higher rate of injection (4 ml/sec), smaller ROI area and lower BMI.
conclusionOur results showed how iodine concentration is highly dependent on some intrinsic and extrinsic parameters of the examination. These parameters should be taken into account since lower concentration of iodine decrease contrast-to-noise ratio, and in longitudinal follow up studies, they would affect iodine quantitive assessments in cancer patients with frequent chemotherapy-induced variations in BMI and cardiac function.
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