Evidence map›Paper›PMID 31600514›Full record

ReviewNeuron2019

Progressive Circuit Changes during Learning and Disease.

Alison L Barth, Ajit Ray

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Molecular Mechanisms for Changing Brain Connectivity in Mice and Humans.International journal of molecular sciences · 2023
    Article
  10. Review
  11. Article
  12. Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Gephyrin-Lacking PV Synapses on Neocortical Pyramidal Neurons.International journal of molecular sciences · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alison L BarthDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA. Electronic address: albarth@andrew.cmu.edu.
Ajit RayDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Carnegie Mellon University · US

Funding

High Throughput Approaches for Cell-Specific Synapse CharacterizationRF1MH114103 · NIMH · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L, BRUCHEZ, MARCEL P · 2017 to 2018
$2.5M
Dynamic connectivity in neocortical networksR01NS088958 · NINDS · CARNEGIE-MELLON UNIVERSITY · PI BARTH, ALISON L · 2016 to 2019
$1.3M
NIMH NIH HHS RF1 MH114103NINDS NIH HHS R01 NS088958
6 · The paper itself

Abstract

A critical step toward understanding cognition, learning, and brain dysfunction will be identification of the underlying cellular computations that occur in and across discrete brain areas, as well as how they are progressively altered by experience or disease. These computations will be revealed by targeted analyses of the neurons that perform these calculations, defined not only by their firing properties but also by their molecular identity and how they are wired within the local and broad-scale network of the brain. New studies that take advantage of sophisticated genetic tools for cell-type-specific identification and control are revealing how learning and neurological disorders initiate and successively change the properties of defined neural circuits. Understanding the temporal sequence of adaptive or pathological synaptic changes across multiple synapses within a network will shed light into how small-scale neural circuits contribute to higher cognitive functions during learning and disease.

Indexed as

Alzheimer DiseaseAnimalsBrainCognitionDecision MakingHippocampusHumansLearningNeocortexNervous System DiseasesNeural PathwaysNeuronal PlasticityNeuronsSynapses

Identifiers

PMID31600514
PMCPMC12038749
OpenAlexW2979330517

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.