Evidence map›Paper›PMID 31600444›Full record

ArticleAnalytical chemistry2019

Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility-Imaging Mass Spectrometry and Unsupervised Segmentation.

Berkley M Ellis, Caleb N Fischer, Leroy B Martin, Brian O Bachmann, John A McLean

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Berkley M Ellis
Caleb N Fischer
Leroy B MartinWaters Corporation , 34 Maple Street , Milford , Massachusetts 01757 , United States.
Vanderbilt University · USWaters (United States) · US

Funding

New Methodologies for Accelerating Natural Product DiscoveryR01GM092218 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, MCLEAN, JOHN ALAN · 2010 to 2018
$2.8M
Ion mobility based informatics and visualization strategies in support of metabolomicsR03CA222452 · NCI · VANDERBILT UNIVERSITY · PI MCLEAN, JOHN ALAN · 2017 to 2017
$152k
Ecological determinants of natural product synthesis in cave myxobacteriaF32GM128344 · NIGMS · VANDERBILT UNIVERSITY · PI FISCHER, CALEB NATHANIEL · 2018 to 2019
$120k
NCI NIH HHS R03 CA222452NIGMS NIH HHS F32 GM128344NIGMS NIH HHS R01 GM092218
6 · The paper itself

Abstract

Imaging the inventory of microbial small molecule interactions provides important insights into microbial chemical ecology and human medicine. Herein we demonstrate a new method for enhanced detection and analysis of metabolites present in interspecies interactions of microorganisms on surfaces. We demonstrate that desorption electrospray ionization-imaging mass spectrometry (DESI-IMS) using microporous membrane scaffolds (MMS) enables enhanced spatiochemical analyses of interacting microbes among tested sample preparation techniques. Membrane scaffolded DESI-IMS has inherent advantages compared to matrix-assisted laser desorption ionization (MALDI) and other IMS methods through direct IMS analyses of microbial chemistry

Indexed as

Membranes, ArtificialMicrobial InteractionsIon Mobility SpectrometrySpectrometry, Mass, Electrospray IonizationMembranes, Artificial

Identifiers

PMID31600444
PMCPMC7331455
OpenAlexW2979759300

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.