Evidence map›Paper›PMID 31600064›Full record

ArticleBioconjugate chemistry2019

Novel Reversible Fluorescent Glycan Linker for Functional Glycomics.

Mohui Wei, Tanya R McKitrick, Akul Y Mehta, Chao Gao, Nan Jia, Alyssa M McQuillan, Jamie Heimburg-Molinaro, Lijun Sun, Richard D Cummings

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohui WeiDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.ORCID 0000-0001-5609-450X
Tanya R McKitrickDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Akul Y MehtaDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Chao GaoDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Nan JiaDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Alyssa M McQuillanDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Jamie Heimburg-MolinaroDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Lijun SunDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.
Richard D CummingsDepartment of Surgery, Beth Israel Deaconess Medical Center , Harvard Medical School , National Center for Functional Glycomics, CLS 11087-3 Blackfan Circle , Boston , Massachusetts 02115 , United States.ORCID 0000-0002-8918-5034

Funding

Overall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9M
NIGMS NIH HHS P41 GM103694
6 · The paper itself

Abstract

To aid in generating complex and diverse natural glycan libraries for functional glycomics, more efficient and reliable methods are needed to derivatize glycans. Here we present our development of a reversible, cleavable bifunctional linker 3-(methoxyamino)propylamine (MAPA). As the fluorenylmethyloxycarbonate (Fmoc) version (F-MAPA), it is highly fluorescent and efficiently derivatizes free reducing glycans to generate closed-ring derivatives that preserve the structural integrity of glycans. A library of glycans were derivatized and used to generate a covalent glycan microarray using

Indexed as

FluorescenceCarbohydrate ConformationGlycomicsGlycoproteinsHumansMicroarray AnalysisPolysaccharidesPropylaminesGlycoproteinsPolysaccharidesPropylamines

Identifiers

PMID31600064
PMCPMC7585744

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.