Evidence map›Paper›PMID 31600061›Full record

ArticleBioconjugate chemistry2019

Protein-Nucleic Acid Conjugation with Sterol Linkers Using Hedgehog Autoprocessing.

Xiaoyu Zhang, Zihan Xu, Dina S Moumin, Daniel A Ciulla, Timothy S Owen, Rebecca A Mancusi, José-Luis Giner, Chunyu Wang, Brian P Callahan

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Enzyme Fragment Complementation Driven by Nucleic Acid Hybridization.bioRxiv : the preprint server for biology · 2023
    Article
  4. RNA-TAG Mediated Protein-RNA Conjugation.Chembiochem : a European journal of chemical biology · 2023
    Article
  5. Review
  6. Review
  7. Enzymatic Beacons for Specific Sensing of Dilute Nucleic Acid.Chembiochem : a European journal of chemical biology · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyu ZhangChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
Zihan XuChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
Dina S MouminChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
Daniel A CiullaChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
Timothy S OwenChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
Rebecca A MancusiChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.
José-Luis GinerDepartment of Chemistry , State University of New York - ESF , Syracuse , New York 13210 , United States.ORCID 0000-0002-8092-5139
Chunyu WangBiology Department , Rensselaer Polytechnic Institute , 110 8th Street , Troy , New York 12180 , United States.ORCID 0000-0001-5165-7959
Brian P CallahanChemistry Department , Binghamton University , Binghamton , New York 13902 , United States.ORCID 0000-0003-4826-0162

Funding

Structural Mechanisms of Hedgehog Autoprocessing in Physiology and DiseaseR01CA206592 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI CALLAHAN, BRIAN PATRICK, WANG, CHUNYU · 2017 to 2021
$2.0M
Predoctoral Training Program for Alzheimer’s Disease at the Interface of Data Science, Engineering and BiologyT32AG078123 · NIA · RENSSELAER POLYTECHNIC INSTITUTE · PI Chunyu Wang · 2023 to 2026
$974k
NCI NIH HHS R01 CA206592NIA NIH HHS T32 AG078123
6 · The paper itself

Abstract

Hedgehog (Hh) precursor proteins contain an autoprocessing domain called HhC whose native function is protein cleavage and C-terminal glycine sterylation. The transformation catalyzed by HhC occurs in

Indexed as

AnimalsDrosophilaDrosophila ProteinsHedgehog ProteinsKineticsNucleic AcidsSterolsDrosophila ProteinsHedgehog Proteinshh protein, DrosophilaNucleic AcidsSterols

Identifiers

PMID31600061
PMCPMC7045895

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.