Evidence map›Paper›PMID 31600059›Full record

ArticleBiomacromolecules2019

Differential Roles of Plasma Protein Corona on Immune Cell Association and Cytokine Secretion of Oligomeric and Fibrillar Beta-Amyloid.

Ava Faridi, Wen Yang, Hannah Gabrielle Kelly, Chuanyu Wang, Pouya Faridi, Anthony Wayne Purcell, Thomas P Davis, Pengyu Chen, Stephen J Kent, Pu Chun Ke

Abstract read
In one paragraph

Article in Biomacromolecules, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ava FaridiARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.
Wen YangMaterials Research and Education Center , Auburn University , Auburn , Alabama 36849 , United States.
Hannah Gabrielle KellyDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity , University of Melbourne , Melbourne , Victoria 3052 , Australia.
Chuanyu WangMaterials Research and Education Center , Auburn University , Auburn , Alabama 36849 , United States.
Pouya FaridiInfection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute , Monash University , Clayton , Victoria 3800 , Australia.
Anthony Wayne PurcellInfection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute , Monash University , Clayton , Victoria 3800 , Australia.ORCID 0000-0003-0532-8331
Thomas P DavisARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.ORCID 0000-0003-2581-4986
Pengyu ChenMaterials Research and Education Center , Auburn University , Auburn , Alabama 36849 , United States.ORCID 0000-0003-3380-872X
Stephen J KentDepartment of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity , University of Melbourne , Melbourne , Victoria 3052 , Australia.ORCID 0000-0002-8539-4891
Pu Chun KeARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences , Monash University , 381 Royal Parade , Parkville , Victoria 3052 , Australia.ORCID 0000-0003-2134-0859

Funding

Purchase of a modularized confocal microscopeR35GM133795 · NIGMS · AUBURN UNIVERSITY AT AUBURN · PI Pengyu Chen · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM133795
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a primary neurological disease with no effective cure. A hallmark of AD is the presence of intracellular tangles and extracellular plaques derived from the aberrant aggregation of tau- and beta-amyloid (Aβ). Aβ presents in the brain as well as in cerebrospinal fluid and the circulation, and Aβ toxicity has been attributed to amyloidosis and inflammation, among other causes. In this study, the effects of the plasma protein corona have been investigated with regard to the blood cell association and cytokine secretion of oligomeric (Aβo) and fibrillar Aβ

Indexed as

Alzheimer DiseaseAmyloidAmyloid beta-PeptidesBrainCytokinesHumansMicrogliaNeuronsPeptide FragmentsPlaque, AmyloidProtein CoronaProtein TransportAmyloidAmyloid beta-PeptidesCytokinesPeptide FragmentsProtein Corona

Identifiers

PMID31600059
PMCPMC9285861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.