ArticleHuman brain mapping2020
Neurovascular coupling in the developing neonatal brain at rest.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- A novel neurovascular coupling analysis method based on simultaneous EEG-fNIRS for investigating the effects of working memory load.Medical & biological engineering & computing · 2026Article
- Understanding variability in full-term newborns' fNIRS data: the impact of birth weight and gestational age on infants' speech perception abilities.Neurophotonics · 2026Article
- Associations between postnatal cerebral oxygen availability and utilization in very to late preterm infants and neurodevelopmental outcome.Scientific reports · 2026Observational
- Neural encoding of auditory rhythm beyond cortical auditory areas before the age of term.iScience · 2025Article
- Real-time monitoring of wavelet-based neurovascular coupling in neonates with hypoxic ischemic encephalopathy using an hourly time window.Neurophotonics · 2025Article
- Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study.Actas espanolas de psiquiatria · 2025Article
- Multimodal fNIRS-EEG sensor fusion: Review of data-driven methods and perspective for naturalistic brain imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cerebral near-infrared spectroscopy guided neonatal intensive care management for the preterm infant.Pediatric research · 2024Review
- Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Haemodynamic Responses to Spontaneous Neural Activity on the Electroencephalogram in Preterm Infants.Advances in experimental medicine and biology · 2024Article
- Preictal neuronal and vascular activity precedes the onset of childhood absence seizure: direct current potential shifts and their correlation with hemodynamic activity.Neurophotonics · 2023Article
- Functional Near-Infrared Spectroscopy as a Personalized Digital Healthcare Tool for Brain Monitoring.Journal of clinical neurology (Seoul, Korea) · 2023Review
- Associations between neurological examination at term-equivalent age and cerebral hemodynamics and oxygen metabolism in infants born preterm.Frontiers in neuroscience · 2023Article
- Activation of NMDA receptors in brain endothelial cells increases transcellular permeability.Fluids and barriers of the CNS · 2022Article
- Early brain activity: Translations between bedside and laboratory.Progress in neurobiology · 2022Review
- Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults.NeuroImage · 2022Article
- Early development of sleep and brain functional connectivity in term-born and preterm infants.Pediatric research · 2022Review
- Assessing cerebral blood flow, oxygenation and cytochrome c oxidase stability in preterm infants during the first 3 days after birth.Scientific reports · 2022Article
- Function and development of interneurons involved in brain tissue oxygen regulation.Frontiers in molecular neuroscience · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neonatal brain is an extremely dynamic organization undergoing essential development in terms of connectivity and function. Several functional imaging investigations of the developing brain have found neurovascular coupling (NVC) patterns that contrast with those observed in adults. These discrepancies are partly due to that NVC is still developing in the neonatal brain. To characterize the vascular response to spontaneous neuronal activations, a multiscale multimodal noninvasive approach combining simultaneous electrical, hemodynamic, and metabolic recordings has been developed for preterm infants. Our results demonstrate that the immature vascular network does not adopt a unique strategy to respond to spontaneous cortical activations. NVC takes on different forms in the same preterm infant during the same recording session in response to very similar types of neural activation. This includes (a) positive stereotyped hemodynamic responses (increases in HbO, decreases in HbR together with increases in rCBF and rCMRO2), (b) negative hemodynamic responses (increases in HbR, decreases in HbO together with decreases in rCBF and rCMRO2), and (c) Increases and decreases in both HbO-HbR and rCMRO2 together with no changes in rCBF. Age-related NVC maturation is demonstrated in preterm infants, which can contribute to a better understanding/prevention of cerebral hemodynamic risks in these infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.