ArticleDepression and anxiety2019
Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder.
Article in Depression and anxiety, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 13 citations in OpenAlex.
- Emotion-specific amygdala habituation in treatment-referred young adults with antisocial histories: links with internalizing and externalizing symptoms and future recidivism.Neuroimage. Reports · 2026Article
- Structural Brain Correlates of Childhood Inhibited Temperament: An ENIGMA-Anxiety Mega-Analysis.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- Genetic Vulnerability to Social Anxiety Disorder.Current topics in behavioral neurosciences · 2025Review
- Intergenerational transmission of brain structure and function in humans: a narrative review of designs, methods, and findings.Brain structure & function · 2024Review
- Pre-COVID brain network topology prospectively predicts social anxiety alterations during the COVID-19 pandemic.Neurobiology of stress · 2023Article
- Trauma exposure among cannabis use disorder individuals was associated with a craving-correlated non-habituating amygdala response to aversive cues.Drug and alcohol dependence reports · 2022Article
- ENIGMA-anxiety working group: Rationale for and organization of large-scale neuroimaging studies of anxiety disorders.Human brain mapping · 2022Review
- Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.EBioMedicine · 2021Article
- Restricted Visual Scanpaths During Emotion Recognition in Childhood Social Anxiety Disorder.Frontiers in psychiatry · 2021Article
- Imaging the socially-anxious brain: recent advances and future prospects.F1000Research · 2020Review
- Investigating microstructure of white matter tracts as candidate endophenotypes of Social Anxiety Disorder - Findings from the Leiden Family Lab study on Social Anxiety Disorder (LFLSAD).NeuroImage. Clinical · 2020Article
- Amygdala hyperreactivity to faces conditioned with a social-evaluative meaning- a multiplex, multigenerational fMRI study on social anxiety endophenotypes.NeuroImage. Clinical · 2020Article
- Impaired neural habituation to neutral faces in families genetically enriched for social anxiety disorder.Depression and anxiety · 2019Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSocial anxiety disorder (SAD) is an incapacitating disorder running in families. Previous work associated social fearfulness with a failure to habituate, but the habituation response to neutral faces has, as of yet, not been investigated in patients with SAD and their family members concurrently. Here, we examined whether impaired habituation to neutral faces is a putative neurobiological endophenotype of SAD by using data from the multiplex and multigenerational Leiden Family Lab study on SAD.
methodsParticipants (n = 110; age, 9.2 - 61.5 years) performed a habituation paradigm involving neutral faces, as these are strong social stimuli with an ambiguous meaning. We used functional magnetic resonance imaging data to investigate whether brain activation related to habituation was associated with the level of social anxiety within the families. Furthermore, the heritability of the neural habituation response was estimated.
resultsOur data revealed a relationship between impaired habituation to neutral faces and social anxiety in the right hippocampus and right amygdala. In addition, our data indicated that this habituation response displayed moderate - to-moderately high heritability in the right hippocampus.
conclusionThe present results provide support for altered habituation as a candidate SAD endophenotype; impaired neural habitation cosegregrated with the disorder within families and was heritable. These findings shed light on the genetic susceptibility to SAD.
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