Evidence map›Paper›PMID 31599702›Full record

ArticleMolecular biology of the cell2019

Reciprocal interactions between mtDNA and lifespan control in budding yeast.

Enrique J Garcia, Janeska J de Jonge, Pin-Chao Liao, Elizabeth Stivison, Cierra N Sing, Ryo Higuchi-Sanabria, Istvan R Boldogh, Liza A Pon

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Yeast as a Model for Human Disease.International journal of molecular sciences · 2026
    Review
  2. Biomolecules · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. In Vivo Imaging with Genetically Encoded Redox Biosensors.International journal of molecular sciences · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Enrique J GarciaDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Janeska J de JongeDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Pin-Chao LiaoDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Elizabeth StivisonDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Cierra N SingDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Ryo Higuchi-SanabriaDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Istvan R BoldoghDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Liza A PonDepartment of Pathology and Cell Biology and Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, New York, NY 10032.
Columbia University · USCornell University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
NUTRITIONT32DK007647 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anthony W Ferrante, Lori M Zeltser · 1990 to 2026
$7.4M
Mitochondrial inheritance and quality controlR35GM122589 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Liza A Pon · 2017 to 2026
$5.1M
MITOCHONDRIAL MOTILITY AND INHERITANCER01GM045735 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI PON, LIZA A · 1993 to 2016
$4.2M
The Role of Actin in Cellular AgingR33AG051047 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2018 to 2020
$1.4M
The Role of Actin in Cellular AgingR21AG051047 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PON, LIZA A · 2016 to 2017
$427k
Molecular and Therapeutic Mechanisms of a new model of Congenital Muscular DystrophyF31AR070013 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GARCIA, ENRIQUE JOSE · 2016 to 2019
$190k
Mitochondria-cytoskeleton communication and function in agingF31AG055326 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SING, CIERRA NICOLE · 2016 to 2020
$179k
The Cytoskeletal Stress Response: A Novel Facet to Protecting Cell Integrity during AgingF32AG053023 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI HIGUCHI-SANABRIA, RYO · 2016 to 2018
$168k
NIAMS NIH HHS F31 AR070013NIA NIH HHS F31 AG055326NIA NIH HHS F32 AG053023NIA NIH HHS R21 AG051047NIA NIH HHS R33 AG051047NIDDK NIH HHS T32 DK007647NIGMS NIH HHS R01 GM045735NIGMS NIH HHS R35 GM122589NIGMS NIH HHS T32 GM007367
6 · The paper itself

Abstract

Loss of mitochondrial DNA (mtDNA) results in loss of mitochondrial respiratory activity, checkpoint-regulated inhibition of cell cycle progression, defects in growth, and nuclear genome instability. However, after several generations, yeast cells can adapt to the loss of mtDNA. During this adaptation, rho

Indexed as

Cell CycleCell DivisionCell ProliferationCellular SenescenceDNA, MitochondrialDNA ReplicationGenomic InstabilityMitochondriaSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomycetalesSilent Information Regulator Proteins, Saccharomyces cerevisiaeDNA, MitochondrialSaccharomyces cerevisiae ProteinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR3 protein, S cerevisiae

Identifiers

PMID31599702
PMCPMC6857569
OpenAlexW2979347011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.