Evidence map›Paper›PMID 31599570›Full record

ArticleACS applied materials & interfaces2019

Covalent Attachment of P15 Peptide to Ti Alloy Surface Modified with Polymer to Enhance Osseointegration of Implants.

Liye Fu, Maiko Omi, Mingkang Sun, Boyle Cheng, Gordon Mao, Tong Liu, Gustavo Mendonça, Saadyah E Averick, Yuji Mishina, Krzysztof Matyjaszewski

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. The dental implant surface: a review of the past, present and future.Journal of materials science. Materials in medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Liye FuDepartment of Chemistry , Carnegie Mellon University , Pittsburgh , Pennsylvania 15213 , United States.ORCID http://orcid.org/0000-0002-7077-5632
Maiko OmiDepartment of Biologic and Materials Sciences & Prothodontics , University of Michigan School of Dentistry , Ann Arbor , Michigan 48109 , United States.
Mingkang SunDepartment of Chemistry , Carnegie Mellon University , Pittsburgh , Pennsylvania 15213 , United States.
Boyle ChengNeuroscience Disruptive Research Lab , Allegheny Health Network , 320 East North Avenue , Pittsburgh , Pennsylvania 15212 , United States.
Gordon MaoNeuroscience Disruptive Research Lab , Allegheny Health Network , 320 East North Avenue , Pittsburgh , Pennsylvania 15212 , United States.
Tong LiuDepartment of Chemistry , Carnegie Mellon University , Pittsburgh , Pennsylvania 15213 , United States.
Gustavo MendonçaDepartment of Biologic and Materials Sciences & Prothodontics , University of Michigan School of Dentistry , Ann Arbor , Michigan 48109 , United States.
Saadyah E AverickNeuroscience Disruptive Research Lab , Allegheny Health Network , 320 East North Avenue , Pittsburgh , Pennsylvania 15212 , United States.ORCID http://orcid.org/0000-0003-4775-2317
Yuji MishinaDepartment of Biologic and Materials Sciences & Prothodontics , University of Michigan School of Dentistry , Ann Arbor , Michigan 48109 , United States.
Krzysztof MatyjaszewskiDepartment of Chemistry , Carnegie Mellon University , Pittsburgh , Pennsylvania 15213 , United States.ORCID http://orcid.org/0000-0003-1960-3402
Carnegie Mellon University · USAllegheny Health Network · USUniversity of Michigan · US

Funding

Molecular pathogenesis of craniosynostosis caused by enhanced BMP signalingR01DE020843 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MISHINA, YUJI · 2010 to 2019
$4.9M
NIDCR NIH HHS R01 DE020843
6 · The paper itself

Abstract

Titanium (Ti) and its alloys are used in orthopedic and dental implants due to their excellent physical properties and biocompatibility. Although Ti exhibits superior osteoconductive properties compared to those of polymer-based implants, improved bone-on growth properties are required for enhanced surgical outcomes and improved recovery surgical interventions. Herein, we demonstrate a novel surface modification strategy to enhance the osteoconductivity of Ti surfaces through the grafting-from procedure of a reactive copolymer via surface-initiated atom transfer radical polymerization (SI-ATRP). Then, postpolymerization conjugation of the P15 peptide, an osteoblast binding motif, was successfully carried out. Subsequent

Indexed as

AlloysAnimalsCell SurvivalCollagenDental ImplantsMiceOsseointegrationOsteoblastsPeptide FragmentsTitaniumAlloyscell-binding peptide P-15CollagenDental ImplantsPeptide FragmentsTitaniumimplantosseointegrationP15 peptidepolymer graftingSI-ATRPsurface modificationtitanium

Identifiers

PMID31599570
PMCPMC6993989
OpenAlexW2979365254

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.