ArticleThe Journal of infectious diseases2020
The Impact of Multiple Rounds of Indoor Residual Spraying on Malaria Incidence and Hemoglobin Levels in a High-Transmission Setting.
Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Indoor residual spraying for preventing malaria in communities using insecticide-treated nets.The Cochrane database of systematic reviews · 2022Pooled it
- Impact of Late-Rainy Season Indoor Residual Spraying on Holoendemic Malaria Transmission: A Cohort Study in Northern Zambia.The Journal of infectious diseases · 2025Article
- Article
- Prevalence of malaria infection and the impact of mosquito bed net distribution among children aged 6-59 months in Ghana: Evidence from the Ghana demographic health and malarial indicator surveys.Parasite epidemiology and control · 2023Article
- East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda.The American journal of tropical medicine and hygiene · 2022Review
- East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings.The American journal of tropical medicine and hygiene · 2022Article
- The influence of the environment and indoor residual spraying on malaria risk in a cohort of children in Uganda.Scientific reports · 2022Article
- Marked reduction in antibiotic usage following intensive malaria control in a cohort of Ugandan children.BMC medicine · 2021Article
- Orientation of Antigen Display on Self-Assembling Protein Nanoparticles Influences Immunogenicity.Vaccines · 2021Article
- Changing malaria fever test positivity among paediatric admissions to Tororo district hospital, Uganda 2012-2019.Malaria journal · 2020Article
- Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo.Malaria journal · 2020Article
- Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda.The American journal of tropical medicine and hygiene · 2020Article
- Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda.The American journal of tropical medicine and hygiene · 2020Article
- The age-specific incidence of hospitalized paediatric malaria in Uganda.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundIndoor residual spraying (IRS) is widely used as a vector control measure, although there are conflicting findings of its effectiveness in reducing malaria incidence. The objective of this study was to estimate the effect of multiple IRS rounds on malaria incidence and hemoglobin levels in a cohort of children in rural southeastern Uganda.
methodsThe study was based upon a dynamic cohort of children aged 0.5-10 years enrolled from August 2011 to June 2017 in Nagongera Subcounty. Confirmed malaria infections and hemoglobin levels were recorded over time for each participant. After each of 4 rounds of IRS, malaria incidence, hemoglobin levels, and parasite density were evaluated and compared with pre-IRS levels. Analyses were carried out at the participant level while accounting for repeated measures and clustering by household.
resultsIncidence rate ratios comparing post-IRS to pre-IRS incidence rates for age groups 0-3, 3-5, and 5-11 were 0.108 (95% confidence interval [CI], .078-.149), 0.173 (95% CI, .136-.222), and 0.226 (95% CI, .187-.274), respectively. The mean hemoglobin levels significantly increased from 11.01 (pre-IRS) to 12.18 g/dL (post-IRS).
conclusionsOur study supports the policy recommendation of IRS usage in a stable and perennial transmission area to rapidly reduce malaria transmission.
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