ArticleMolecular omics2019
Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy.
Article in Molecular omics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Association of maternal blood metabolomics and gestational diabetes mellitus risk: a systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2025Pooled it
- Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes.Diabetologia · 2023Trial
- Altered Lipid Metabolism in Obese Women With Gestational Diabetes and Associations With Offspring Adiposity.The Journal of clinical endocrinology and metabolism · 2022Trial
- Prenatal Chromium Exposure and Gestational Diabetes Mellitus: Integrating Genetic and Epigenetic Regulation of LPCAT1 from a Phospholipid Remodeling Perspective.Biological trace element research · 2026Article
- Lipid profiles and risk of gestational diabetes mellitus in women with isolated TPOAb positivity during early pregnancy.Scientific reports · 2026Article
- Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis.Frontiers in endocrinology · 2026Article
- Comprehensive first-trimester targeted metabolomics for early prediction and understanding of GDM pathophysiology.Frontiers in molecular biosciences · 2026Article
- Quercetin's regulation of glucose and lipid metabolism in gestational diabetes mellitus: role of the PCSK9/LDLR axis.Nutrition & metabolism · 2025Article
- Article
- Systemic analyses show that the biosynthesis and spatial distribution of fatty acids, triglycerides and lipids differed in male and female mice and humans.Open biology · 2025Article
- Biomarkers predicting adverse pregnancy outcomes in women living with obesity: a systematic review and meta-analysis.AJOG global reports · 2025Review
- Metabolic Roles of Fatty Acid Binding Protein 4 (FABP4) in Fetal and Maternal Health and Maintenance of Pregnancy in Women with Obesity: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Maternal lipids in overweight and obesity: implications for pregnancy outcomes and offspring's body composition.Seminars in immunopathology · 2025Review
- Exploring the molecular intersection for hypertension, hyperlipidemia and their comorbid conditions through multi-omics approaches.Frontiers in cardiovascular medicine · 2025Article
- Article
- Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight.Diabetologia · 2024Article
- Systemic analysis of lipid metabolism from individuals to multi-organism systems.Molecular omics · 2024Article
- A co-ordinated transcriptional programme in the maternal liver supplies long chain polyunsaturated fatty acids to the conceptus using phospholipids.Nature communications · 2024Article
- Body composition in second trimester is associated with dyslipidemia in third trimester.Archives of gynecology and obstetrics · 2024Article
- First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls.Frontiers in molecular biosciences · 2024Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Gestational diabetes (GDM), a common pregnancy complication associated with obesity and long-term health risks, is usually diagnosed at approximately 28 weeks of gestation. An understanding of lipid metabolism in women at risk of GDM could contribute to earlier diagnosis and treatment. We tested the hypothesis that altered lipid metabolism at the beginning of the second trimester in obese pregnant women is associated with a diagnosis of GDM. Plasma samples from 831 participants (16-45 years, 15-18 weeks gestation, BMI ≥ 30) from the UPBEAT study of obese pregnant women were used. The lipid, sterol and glyceride fraction was isolated and analysed in a semi-quantitative fashion using direct infusion mass spectrometry. A combination of uni-, multi-variate and multi-variable statistical analyses was used to identify candidate biomarkers in plasma associated with a diagnosis of GDM (early third trimester; IADPSG criteria). Multivariable adjusted analyses showed that participants who later developed GDM had a greater abundance of several triglycerides (48:0, 50:1, 50:2, 51:5, 53:4) and phosphatidylcholine (38:5). In contrast sphingomyelins (32:1, 41:2, 42:3), lyso-phosphatidylcholine (16:0, 18:1), phosphatidylcholines (35:2, 40:7, 40:10), two polyunsaturated triglycerides (46:5, 48:6) and several oxidised triglycerides (48:6, 54:4, 56:4, 58:6) were less abundant. We concluded that both lipid and triglyceride metabolism were altered at least 10 weeks before diagnosis of GDM. Further investigation is required to determine the functional consequences of these differences and the mechanisms by which they arise.
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Registered trials
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