Evidence map›Paper›PMID 31598930›Full record

Trial reportJournal of thrombosis and thrombolysis2020

Relative risk of plaque erosion among different age and sex groups in patients with acute coronary syndrome.

Hyung Oh Kim, Chong Jin Kim, Weon Kim, Jin-Man Cho, Tsunenari Soeda, Masamichi Takano, Bryan P Yan, Filippo Crea, Giampaolo Niccoli, Rocco Vergallo and 15 more

Abstract readClinical TrialMulticenter Study
PubMed Publisher
In one paragraph

Trial report in Journal of thrombosis and thrombolysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Review
  3. Pathogenesis of plaque erosion.Trends in cardiovascular medicine · 2026
    Review
  4. The Triglyceride-Glucose Index is associated with hospital and Intensive Care Unit Mortality in critically ill patients with Acute Coronary Syndrome.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Observational
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Hyung Oh KimCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Chong Jin KimDepartment of Cardiovascular Medicine, Kyung Hee University, Seoul, South Korea.
Weon KimDepartment of Cardiovascular Medicine, Kyung Hee University, Seoul, South Korea.
Jin-Man ChoDepartment of Cardiovascular Medicine, Kyung Hee University, Seoul, South Korea.
Tsunenari SoedaDepartment of Cardiovascular Medicine, Nara Medical University, Kashihara, Nara, Japan.
Masamichi TakanoCardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Chiba, Japan.
Bryan P YanDivision of Cardiology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Sha Tin, Hong Kong.
Filippo CreaDepartment of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy.
Giampaolo NiccoliDepartment of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy.
Rocco VergalloDepartment of Cardiovascular and Thoracic Science, Catholic University of the Sacred Heart, Rome, Italy.
Yoshiyasu MinamiDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.
Takumi HigumaDivision of Cardiology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Shigeki KimuraDivision of Cardiology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Niklas Frederik BoederDepartment of Cardiology, University of Giessen, Giessen, Germany.
Holger NefDepartment of Cardiology, University of Giessen, Giessen, Germany.
Tom AdriaenssensDepartment of Cardiovascular Medicine, University Hospitals Leuven, Louvain, Belgium.
Osamu KuriharaCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Vikas ThondapuCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Michele RussoCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Erika YamamotoCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Tomoyo SugiyamaCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA.
Hang LeeDivision of Biostatistics, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tsunekazu KakutaDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Tsuchiura, Ibaraki, Japan.
Taishi YonetsuDepartment of Interventional Cardiology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo Ward, Tokyo, 113-8519, Japan. t-yonetsu.cvm@tmd.ac.jp.
Ik-Kyung JangCardiology Division, Massachusetts General Hospital, Harvard Medical School, GRB 800, 55 Fruit Street, Boston, MA, 02114, USA. ijang@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmortem studies reported plaque erosion is frequent in young women. Recent in vivo studies failed to show age and sex differences in the plaque erosion prevalence. The aim of this study was to investigate the prevalence of plaque erosion by age and sex among acute coronary syndromes (ACS) patients. From 1699 ACS patients, 1083 with plaque erosion or rupture were analyzed. Patients were categorized as 5 age groups (≤ 50, 51-60, 61-70, 71-80, ≥ 81 years). Overall prevalence of plaque erosion was similar between males and females (p = 0.831). Males age ≤ 50 had higher (p = 0.018) and age 71-80 had lower (p = 0.006) prevalence of plaque erosion. Females age 61-70 had higher (p = 0.021) and age 71-80 had lower (p = 0.045) prevalence of plaque erosion. In advanced age groups (≥ 71 years), rupture was the dominant etiology in both sexes. In multivariate analysis of males, age ≤ 50 demonstrated a trend to increase (OR 1.418, 95% CI 0.961-2.093, p = 0.078) the erosion risk. Females age ≤ 70 independently increased (OR 2.138, 95% CI 1.249-3.661, p = 0.006) the risk for erosion. The prevalence of plaque erosion was similar between males and females. Plaque erosion risk was increased in the males age ≤ 50 and in the females age ≤ 70 among ACS patients.

Indexed as

Acute Coronary SyndromePlaque, AtheroscleroticAgedAged, 80 and overAge FactorsFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsSex FactorsAcute coronary syndromeAgingPlaque erosionSex

Identifiers

PMID31598930

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.