Evidence map›Paper›PMID 31598881›Full record

ArticleFrontiers of medicine2019

Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5

Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li

Abstract read
PubMed Publisher
In one paragraph

Article in Frontiers of medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hui JiangENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
Shan ZengENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
Wenli NiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China.
Yan ChenENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China. chenyan0528@fudan.edu.cn.
Wenyan LiENT Institute and Otorhinolaryngology Department of Affiliated Eye and ENT Hospital, Fudan University, Shanghai, 200031, China. wenyan_li2000@126.com.
Eye & ENT Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnt and Notch signaling play crucial roles in the determination of the prosensory domain and in the differentiation of hair cells (HCs) and supporting cells during mouse inner ear development; however, the relationship between the two signaling pathways in the mouse cochlea remains largely unknown. Here, we investigated the interactions between Notch and Wnt signaling on the basis of the bidirectional regulation of Notch1 specifically in Wnt-responsive Lgr5

Indexed as

AnimalsAnimals, NewbornCell DifferentiationCochleaFemaleHair Cells, AuditoryMaleMiceReceptor, Notch1Receptors, G-Protein-CoupledSignal TransductionStem CellsWnt Signaling PathwayLgr5 protein, mouseNotch1 protein, mouseReceptor, Notch1Receptors, G-Protein-Coupledauditory systemcochlearinner earLgr5NotchWnt

Identifiers

PMID31598881
OpenAlexW2979299306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.