Evidence map›Paper›PMID 31598819›Full record

ArticleMolecular diversity2020

Efficient and environmentally sustainable domino protocol for the synthesis of diversified spiroheterocycles with privileged heterocyclic substructures using bio-organic catalyst in aqueous medium.

Kanchan Verma, Yogesh Kumar Tailor, Sarita Khandelwal, Esha Rushell, Monu Agarwal, Mahendra Kumar

Abstract read
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In one paragraph

Article in Molecular diversity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kanchan VermaDepartment of Chemistry, University of Rajasthan, Jaipur, India.
Yogesh Kumar TailorDepartment of Chemistry, University of Rajasthan, Jaipur, India.
Sarita KhandelwalDepartment of Chemistry, University of Rajasthan, Jaipur, India.
Esha RushellDepartment of Chemistry, University of Rajasthan, Jaipur, India.
Monu AgarwalDepartment of Chemistry, University of Rajasthan, Jaipur, India.
Mahendra KumarDepartment of Chemistry, University of Rajasthan, Jaipur, India. mahendrakpathak@gmail.com.ORCID http://orcid.org/0000-0001-9413-0807

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An efficient and environmentally sustainable synthetic protocol has been presented to synthesize structurally diverse spiroxindoles spiroannulated with indenopyrroloimidazoles, pyranopyrroloimidazoles, chromenopyrroloimidazoles, and imidazopyrrolopyrimidines involving three-component reaction of isatins, hydantoin, and β-diketones in the presence of green and sustainable bio-organic catalyst, β-amino acid, 2-aminoethanesulfonic acid (taurine), in aqueous media. The synthetic efficiency, operational simplicity, and reusability of catalyst make the present synthetic protocol cost effective, time efficient, and eco-friendly to synthesize molecules with structural diversity and molecular complexity and expected to contribute significantly not only to drug discovery research but also to pharmaceutical and medicinal chemistry.

Indexed as

Amino AcidsCatalysisChemistry, PharmaceuticalDrug DiscoveryHeterocyclic CompoundsImidazolesTaurineWaterAmino AcidsHeterocyclic CompoundsimidazoleImidazolesTaurineWaterBio-organic catalystEnvironmentally sustainableMulticomponent reactionsPyrroloimidazolesSpiroheterocycles

Identifiers

PMID31598819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.