ArticlePituitary2019
Double pituitary adenomas in a large surgical series.
Article in Pituitary, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Double pituitary adenomas: report of two cases and systematic review of the literature.Frontiers in endocrinology · 2024Pooled it
- Clinical management challenges of Cushing's disease associated with double pituitary adenomas: four cases and literature review.Endocrine · 2026Review
- Article
- Double pituitary adenoma associated with acromegaly and hyperprolactinemia: a case report.Archives of endocrinology and metabolism · 2025Article
- Double PitNETs: A Case Report and Literature Review.Cancers · 2025Review
- Exploring the Role of the TAS2R16 Protein and Its Single Nucleotide Variants in Pituitary Adenoma Development.Biomedicines · 2024Article
- A clinicopathological study of non-functioning pituitary neuroendocrine tumours using the World Health Organization 2022 classification.Frontiers in endocrinology · 2024Article
- A rare case of double pituitary prolactinomas: the diagnostic application of intraoperative ultrasonography and DNA methylation markers.Archives of endocrinology and metabolism · 2024Article
- Consecutive resections of double pituitary adenoma for resolution of Cushing disease: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Double pituitary neuroendocrine tumors in a patient with normal growth hormone level acromegaly: A case report and review of the literature.Surgical neurology international · 2023Article
- Multiple tumorous lesions of the pituitary gland.Hormones (Athens, Greece) · 2022Article
- Article
- Double adenomas of the pituitary reveal distinct lineage markers, copy number alterations, and epigenetic profiles.Pituitary · 2021Article
- Metachronous Double Pituitary Adenoma with Altered Transcriptional Factor Profile: A Case Report and Literature Review.NMC case report journal · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo explore the incidence of double pituitary adenomas in a tertiary center for pituitary surgery and asses their clinical, imaging and histopathological features.
methodsThe medical records of the patients operated on for pituitary tumors at the Department of Neurosurgery of Military Institute of Medicine in Warsaw, Poland between the years 2003 and 2018 were retrospectively analyzed. Among the 3270 treated patients, the diagnosis of double pituitary adenoma was established in 22 patients. Clinical, laboratory, detailed histopathological and diagnostics imaging data were collected and analyzed.
resultsThere were 21 cases of synchronous and one case of asynchronous double pituitary adenoma. The main clinical finding was acromegaly (12/22) followed by Cushing's disease (3/22). The diagnosis of synchronous double pituitary adenoma was suspected in the preoperative MRI in 11 patients. In the remaining patients the diagnosis of contiguous double pituitary adenoma was confirmed in the histopathological examination. There was no predilection for gender and the mean observation time was 74.2 months. In one case of Cushing's disease the occurrence of double pituitary adenoma led to the initial failure of achieving hormonal remission. One patient presented with double pituitary adenomas as a manifestation of Carney complex.
conclusionsDouble pituitary adenoma is a rare entity that can pose a significant challenge especially in the setting of Cushing's disease. Careful inspection of preoperative MRI and diagnostic work-up before transsphenoidal surgery and thorough histopathological microscopic examinations with immunohistochemical staining for all pituitary hormones is essential for establishing the diagnosis of double pituitary adenoma.
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