ArticleClinical and experimental medicine2019
IL-8 gene locus is associated with risk, severity and 28-day mortality of sepsis in a Chinese population.
Article in Clinical and experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The association between interleukin-8 gene polymorphism and the risk of sepsis in older adults.Journal of orthopaedic surgery and research · 2024Pooled it
- Circulating Toll-like receptor and cytokine profiles and genetic polymorphisms in a Chinese sepsis cohort: potential links to neuroinflammation and blood-brain barrier dysfunction.Frontiers in immunology · 2026Article
- The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- The association between interleukin-8 gene-251 A/T polymorphism and sepsis: A protocol for systematic review and meta analysis.Medicine · 2021Article
- Plasma PCSK9 levels and sepsis severity: an early assessment in the emergency department.Clinical and experimental medicine · 2021Article
- Investigation of the IL-1β +3954 C>T polymorphism and the risk of sepsis: A case-control study.Medicine · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL)-8 has been reported to be associated with the progression of sepsis. Recent studies have explored the relationship between the IL-8 - 251 A/T polymorphism and sepsis risk. This study evaluated the association between the IL-8 - 251 A/T polymorphism and sepsis susceptibility in a Chinese Han population. We designed a case-control study with 254 sepsis cases and 322 controls. Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. SPSS 20.0 software was used for all statistical analysis (SPSS Inc., Chicago, USA). This study showed that the IL-8 - 251 A/T polymorphism was associated with a decreased risk of sepsis. Stratified analyses found that this association held true in females, non-smokers, and older individuals (age > 60 years). The IL-8 - 251 A/T polymorphism was also related to the severity and 28-day mortality of sepsis. The IL-8 - 251 A/T polymorphism is associated with a decreased risk of sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.