ReviewJournal of neural transmission (Vienna, Austria : 1996)2020
Visceral pain from colon and rectum: the mechanotransduction and biomechanics.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06145945 (A Randomized Controlled Study of the Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study of the Effect of Intraperitoneal Ropivacaine on Visceral Pain After Laparoscopic Gastrectomy
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Hospitalization rate and patterns of clinical reasons among Mpox-confirmed cases: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.Acta biomaterialia · 2026Article
- Suppression of visceral nociception by C-fiber transmission block using temporal interference sinusoidal stimulation.Pain reports · 2026Article
- Mechanism, Dose, and Administration of Dexmedetomidine in Managing Visceral Pain Associated With Surgery: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.International journal of medical sciences · 2026Review
- Article
- Methods for quantitative analyses of nerve fiber deformation in the myenteric plexus under loading of mouse distal colon and rectum.Medical engineering & physics · 2025Article
- Mechanistic Insights From Reduced Bladder Preparations: A Necessary Complement to In Vivo Models.Lower urinary tract symptoms · 2025Article
- PIEZO Channels in Mechano-Inflammation: Gatekeepers of Neuroimmune Crosstalk.Diseases (Basel, Switzerland) · 2025Review
- Therapeutic Potential of Calcium Channel Blockers in Neuropsychiatric, Endocrine and Pain Disorders.Cells · 2025Review
- Atypical cause of radiating leg pain: Visceral referred pain due to ulcerative colitis.Radiology case reports · 2025Article
- Article
- Understanding mechanotransduction in the distal colon and rectum via multiscale and multimodal computational modeling.Journal of the mechanical behavior of biomedical materials · 2024Article
- Forces Bless You: Mechanosensitive Piezo Channels in Gastrointestinal Physiology and Pathology.Biomolecules · 2024Review
- Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.Gastroenterology · 2024Review
- Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Sex differences in zymosan-induced behavioral visceral hypersensitivity and colorectal afferent sensitization.American journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Mechanosensing Piezo channels in gastrointestinal disorders.The Journal of clinical investigation · 2023Review
- The Role of Ion Channels in Functional Gastrointestinal Disorders (FGID): Evidence of Channelopathies and Potential Avenues for Future Research and Therapeutic Targets.International journal of molecular sciences · 2023Review
- Mechanobiological considerations in colorectal stapling: Implications for technology development.Surgery open science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Visceral pain is the cardinal symptom of functional gastrointestinal (GI) disorders such as the irritable bowel syndrome (IBS) and the leading cause of patients' visit to gastroenterologists. IBS-related visceral pain usually arises from the distal colon and rectum (colorectum), an intraluminal environment that differs greatly from environment outside the body in chemical, biological, thermal, and mechanical conditions. Accordingly, visceral pain is different from cutaneous pain in several key psychophysical characteristics, which likely underlies the unsatisfactory management of visceral pain by drugs developed for other types of pain. Colorectal visceral pain is usually elicited from mechanical distension/stretch, rather than from heating, cutting, pinching, or piercing that usually evoke pain from the skin. Thus, mechanotransduction, i.e., the encoding of colorectal mechanical stimuli by sensory afferents, is crucial to the underlying mechanisms of GI-related visceral pain. This review will focus on colorectal mechanotransduction, the process of converting colorectal mechanical stimuli into trains of action potentials by the sensory afferents to inform the central nervous system (CNS). We will summarize neurophysiological studies on afferent encoding of colorectal mechanical stimuli, highlight recent advances in our understanding of colorectal biomechanics that plays critical roles in mechanotransduction, and review studies on mechano-sensitive ion channels in colorectal afferents. This review calls for focused attention on targeting colorectal mechanotransduction as a new strategy for managing visceral pain, which can also have an added benefit of limited CNS side effects, because mechanotransduction arises from peripheral organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.