Observational studyPediatric cardiology2019
Left Ventricular Diastolic Dysfunction and Diastolic Heart Failure in Preterm Infants.
Observational study in Pediatric cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Diastolic function in newborn infants: understanding pathophysiology, diagnosis and clinical relevance.Pediatric research · 2026Review
- Evaluation of Biventricular Diastolic Function in Preterm Infants in the First Week of Postnatal Life.Pediatric cardiology · 2026Observational
- Variable clinical and hemodynamic effect of sildenafil in extreme premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Early left ventricular diastolic function and disease severity in congenital diaphragmatic hernia.Pediatric research · 2025Article
- Reference ranges of left ventricular diastolic multimodal ultrasound parameters in stable preterm infants in the early and late neonatal intensive care admission period.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- [Research progress on the diagnosis of pediatric heart failure].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Longitudinal evaluation of hemodynamic blood and echocardiographic biomarkers for the prediction of BPD and BPD-related pulmonary hypertension in very-low-birth-weight preterm infants.European journal of pediatrics · 2024Observational
- Elevated pulmonary capillary wedge pressure, higher blood pressure, and lower cardiac index in infants with bronchopulmonary dysplasia.International journal of cardiology · 2024Article
- Natural History of Secundum ASD in Preterm and Term Neonates: A Comparative Study.Pediatric cardiology · 2024Article
- The association between patterns of early respiratory disease and diastolic dysfunction in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Heart Failure with Preserved Ejection Fraction in Children.Pediatric cardiology · 2023Review
- Assessment of Indicators of Left Ventricular Performance Obtained by Tissue Doppler Imaging in Prematurely Born Neonates.Journal of cardiovascular development and disease · 2022Article
- Feasibility, Reproducibility and Reference Ranges of Left Atrial Strain in Preterm and Term Neonates in the First 48 h of Life.Diagnostics (Basel, Switzerland) · 2022Article
- Role of left atrial hypertension in pulmonary hypertension associated with bronchopulmonary dysplasia.Frontiers in pediatrics · 2022Article
- Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.JCI insight · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Diastolic dysfunction is primarily an echocardiographic diagnosis. Its clinical counterpart is diastolic heart failure, where the heart has difficulty to fill at normal pressure and the patient develops signs of pulmonary edema. Although diastolic dysfunction is common in adults, limited information is available in preterm infants. The aim of this study is to explore left ventricular diastolic dysfunction and diastolic heart failure in preterm infants and describe clinical manifestations in this population. This is a retrospective observational study in preterm infants < 30 weeks' gestation who received an echocardiography in the first 4 weeks after birth. Diastolic dysfunction was graded using a population-specific adapted version of the adult recommendations for the evaluation of left ventricular diastolic function by echocardiography. Left ventricular diastolic dysfunction was absent, indeterminate, and definite in 82%, 14%, and 4% of the 168 echocardiograms analyzed, and is associated with increased respiratory signs and respiratory deterioration at 48 h before echocardiogram. In seven infants, diastolic heart failure was diagnosed with both ultrasound and clinical signs. The cumulative risk of diastolic dysfunction increased with the increasing postnatal age and a patent ductus arteriosus. Evidence of left ventricular diastolic dysfunction on echocardiography is relatively common in preterm infants, while the left ventricular diastolic heart failure is less frequent. Prolonged exposure to volume load was the most common cause.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.