ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2019
Standardization of Minimally Invasive Tissue Sampling Specimen Collection and Pathology Training for the Child Health and Mortality Prevention Surveillance Network.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 66 citations in OpenAlex.
- Causes of Death Among Stillbirths and Children Aged <5 Years in Africa and South Asia - Child Health and Mortality Prevention Surveillance, Seven Countries, 2016-2024.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2026Article
- Tissue distribution of Histoplasma capsulatum in deceased people living with HIV assessed by minimally invasive tissue sampling: An autopsy-based case series in the Brazilian Amazon.PLoS neglected tropical diseases · 2026Observational
- Infectious pathogens associated with stillbirth and under-five mortality by sickle cell disease in Western Kenya: a cross-sectional study.BMC infectious diseases · 2026Article
- [Minimally invasive autopsies-Methods and limitations].Pathologie (Heidelberg, Germany) · 2026Review
- Rationale and Design of the MIA Trial: A Proof-of-Concept Study of Minimally Invasive Autopsy in an Infectious Cause of Death in a Scandinavian ICU Setting.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026Review
- Introducing Minimally Invasive Tissue Sampling to Ascertain Cause of Death in Children and Stillbirths in Central Mozambique.The American journal of tropical medicine and hygiene · 2026Article
- Article
- Knowledge, acceptability, and attitudes regarding minimally invasive tissue sampling (MITS) techniques in Brazil.PLOS global public health · 2026Article
- International Society of Paediatric Surgical Oncology (IPSO) Minimally Invasive Surgery (MIS) Guidelines.Ecancermedicalscience · 2026Article
- Major Causes of Perinatal and Paediatric Mortality in Sub-Saharan Africa and South Asia: Adjustment for Selection Bias in the CHAMPS Network.Paediatric and perinatal epidemiology · 2025Article
- Diagnostic accuracy of a simplified minimally invasive tissue sampling protocol for stillbirths in low-resource settings.BMJ global health · 2025Article
- Post-mortem study of endemic human coronaviruses (HCoV-NL63, OC43, 229E and HKU-1) in deaths of children under five in low- and middle-income countries: Findings from the Child Health and Mortality Prevention Surveillance (CHAMPS) study.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2025Article
- Article
- Acceptability of minimal invasive tissue sampling (MITS) for stillbirths in Eastern Uganda.PloS one · 2025Article
- The role of minimally invasive surgery in paediatric mediastinal masses and thoracic tumours.Ecancermedicalscience · 2025Article
- Postmortem point-of care hemoglobin testing is feasible and potentially accurate among children in South Africa.PLOS global public health · 2025Article
- Etiologies and comorbidities of meningitis deaths in children under 5 years in high-mortality settings: Insights from the CHAMPS Network in the post-pneumococcal vaccine era.The Journal of infection · 2024Observational
- SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.BMC pregnancy and childbirth · 2024Article
- Neurological Symptoms and Cause of Death Among Young Children in Low- and Middle-Income Countries.JAMA network open · 2024Article
- The discrepancy of antemortem clinical diagnosis and postmortem autopsy diagnosis of lung pathologies in under-five deaths and the reasons for discrepancies: a case series analysis.BMC pediatrics · 2024Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMinimally invasive tissue sampling (MITS) is a simplified postmortem examination technique that has shown to be an adequate approach for cause of death investigation in low-resource settings. It requires relatively low level of infrastructures and can be performed by health professionals with no background in pathology. A training program has been developed for the Child Health and Mortality Prevention Surveillance (CHAMPS) network to guarantee standardization of specimen collection techniques, procedures, and laboratory methods.
methodsThe training program has included assessment of the site capacities and training on a standardized protocol of MITS sampling and histological processing. The project has also introduced a program of training for trainers for the personnel from Mozambique. To guarantee the adequacy of the procedure in each site, a trainer accompanied the local teams when the activities started. Training outcomes were assessed by evaluating the quality of the samples obtained and the quality of the slides produced locally.
resultsBetween June 2016 and October 2018, the laboratories of 7 sites (Bangladesh, Ethiopia, Kenya, Mali, Mozambique, Sierra Leone, and South Africa) have been evaluated and upgraded. Training has been delivered to 63 staff members from all sites. More than 600 MITS procedures have been performed. The quantity of tissue obtained in the MITS by the local teams was sufficient or abundant in 73%, and 87% of the slides were considered as technically acceptable or excellent.
conclusionsSatisfactory standardization of MITS and histology procedures has been achieved across all CHAMPS sites through organized capacity-building plans.
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